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    Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization
    2.
    发明申请
    Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization 有权
    通过免疫诱导高度特异性的抗体到半抗原但不是载体肽

    公开(公告)号：US20150098935A1

    公开(公告)日：2015-04-09

    申请号：US14377126

    申请日：2013-02-08

    申请人： Walter Reed Army Institute of Research

    发明人： Carl R. Alving ,  Gary R. Matyas ,  Arthur E. Jacobson ,  Fuying Li ,  Malliga R. Iyer ,  Kenner C. Rice ,  Kejun Cheng ,  Alexander Mayorov

    IPC分类号： C07D497/08 ,  C07K16/18 ,  A61K47/48

    CPC分类号： C07D497/08 ,  A61K31/439 ,  A61K31/485 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

    摘要： In this application Is described a composition and method for Inducing In a subject anti-hapten antibodies without Inducing antibodies to the carrier protein. Kits for designing and making compositions with desired haptens are also described. In this application Is disclosed a synthetic liposome composition comprising liposomes (L) containing monophosphoryl lipid A (MPLA) [L(MPLA)] and an immunoconjugate comprising a carrier and a hapten. In one embodiment, the carrier is a 23 amino acid hydrophobic membrane proximal external region peptide (MPER) derived from the gp41 transmembrane protein of HIV-1 that spontaneously associates with the outer surface of bilayers of liposomes containing MPLA during liposome formation.

    摘要翻译： 在本申请中描述了用于诱导受试者抗半抗原抗体而不诱导对载体蛋白的抗体的组合物和方法。 还描述了用于设计和制备具有期望的半抗原的组合物的试剂盒。 在本申请中公开了包含含有单磷酰脂质A（MPLA）[L（MPLA）]的脂质体（L）和包含载体和半抗原的免疫缀合物的合成脂质体组合物。 在一个实施方案中，载体是衍生自HIV-1的gp41跨膜蛋白的23个氨基酸疏水性膜近端外部区域肽（MPER），其在脂质体形成期间与含有MPLA的脂质体的双层的外表面自发缔合。