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1.发明授权Bicycloalkyl derivatives of prostaglandins 11-deoxy-PGE.sub.2 acids and esters 失效前列腺素的二环烷基衍生物11-deoxy-PGE {HD 2 {B acids and esters
公开(公告)号：US4115438A
公开(公告)日：1978-09-19
申请号：US817622
申请日：1977-07-21
申请人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
发明人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
IPC分类号： A61K31/12 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/557 , A61P43/00 , C07C33/44 , C07C43/30 , C07C45/00 , C07C45/63 , C07C49/23 , C07C49/613 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/83 , C07C177/00
CPC分类号： C07D307/83 , C07C33/44 , C07C405/00 , Y02P20/55 , Y02P20/582
摘要： Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
摘要翻译： 前列腺素A，E和F的新型双环烷基类似物或衍生物是平滑肌活性的有用修饰剂。 这些化合物具有有价值的药理学性质，如血小板抗聚集剂和胃抑制剂。 这些化合物也是增加股动脉血流和降低血压和心率的宝贵药理作用。
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2.发明授权Bicycloalkyl derivatives of prostaglandins: 11-deoxy-PGE.sub.1 acids and esters 失效前列腺素的双环烷基衍生物：11-脱氧PGE {HD 1 {B酸和酯
公开(公告)号：US4108892A
公开(公告)日：1978-08-22
申请号：US818056
申请日：1977-07-22
申请人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
发明人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
IPC分类号： A61K31/12 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/557 , A61P43/00 , C07C33/44 , C07C43/30 , C07C45/00 , C07C45/63 , C07C49/23 , C07C49/613 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/83 , C07C177/00
CPC分类号： C07D307/83 , C07C33/44 , C07C405/00 , Y02P20/55 , Y02P20/582
摘要： Novel bicycloalkyl analogues or derivatives of prostaglandin A, E, and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
摘要翻译： 前列腺素A，E和F的新型双环烷基类似物或衍生物是平滑肌活性的有用修饰剂。 这些化合物具有有价值的药理学性质，如血小板抗聚集剂和胃抑制剂。 这些化合物也是增加股动脉血流和降低血压和心率的宝贵药理作用。
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3.发明授权
公开(公告)号：US4115453A
公开(公告)日：1978-09-19
申请号：US818057
申请日：1977-07-22
申请人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
发明人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
IPC分类号： A61K31/12 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/557 , A61P43/00 , C07C33/44 , C07C43/30 , C07C45/00 , C07C45/63 , C07C49/23 , C07C49/613 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/83 , C07C49/46
CPC分类号： C07D307/83 , C07C33/44 , C07C405/00 , Y02P20/55 , Y02P20/582
摘要： Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
摘要翻译： 前列腺素A，E和F的新型双环烷基类似物或衍生物是平滑肌活性的有用修饰剂。 这些化合物具有有价值的药理学性质，如血小板抗聚集剂和胃抑制剂。 这些化合物也是增加股动脉血流和降低血压和心率的宝贵药理作用。
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公开(公告)号：US4074063A
公开(公告)日：1978-02-14
申请号：US657221
申请日：1976-02-11
申请人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
发明人： Warren Dexter Woessner , Charles John Sih , Harold Clinton Kluender , Henry Clifford Arndt , William Gerard Biddlecom
IPC分类号： A61K31/12 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/557 , A61P43/00 , C07C33/44 , C07C43/30 , C07C45/00 , C07C45/63 , C07C49/23 , C07C49/613 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/83 , C07C177/00
CPC分类号： C07D307/83 , C07C33/44 , C07C405/00 , Y02P20/55 , Y02P20/582
摘要： Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
摘要翻译： 前列腺素A，E和F的新型双环烷基类似物或衍生物是平滑肌活性的有用修饰剂。 这些化合物具有有价值的药理学性质，如血小板抗聚集剂和胃抑制剂。 这些化合物也是增加股动脉血流和降低血压和心率的宝贵药理作用。
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公开(公告)号：US4029698A
公开(公告)日：1977-06-14
申请号：US627627
申请日：1975-10-31
申请人： Warren Dexter Woessner , William Gerard Biddlecom , Henry Clifford Arndt , George Peter Peruzzotti , Charles John Sih
发明人： Warren Dexter Woessner , William Gerard Biddlecom , Henry Clifford Arndt , George Peter Peruzzotti , Charles John Sih
IPC分类号： C07C35/48 , C07C405/00 , C07C177/00
CPC分类号： C07C35/48 , C07C405/00
摘要： Analogues of prostaglandins E and F, in which the C.sub.15 hydroxyl group is incorporated into a cycloalkylidene moiety, stimulate smooth muscle.
摘要翻译： 前列腺素E和F的类似物，其中C15羟基被引入环亚烷基部分，刺激平滑肌。
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公开(公告)号：US4066834A
公开(公告)日：1978-01-03
申请号：US624099
申请日：1975-10-20
申请人： Warren Dexter Woessner , William Gerard Biddlecom , Henry Clifford Arndt , George Peter Peruzzotti , Charles John Sih
发明人： Warren Dexter Woessner , William Gerard Biddlecom , Henry Clifford Arndt , George Peter Peruzzotti , Charles John Sih
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.
摘要翻译： 前列腺素A，E和F的类似物，其中天然前列腺素的C13-C20链被环烯基或羟基环烯基部分代替，使得亚乙烯基和环的羟基分别在C13-C14保持其自然连续位置 和C15，体外抑制血小板聚集，并在体内显示出有用的心血管活性。
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公开(公告)号：US3989744A
公开(公告)日：1976-11-02
申请号：US384075
申请日：1973-07-30
申请人： Warren Dexter Woessner , Henry Clifford Arndt , William Gerard Biddlecom , George Peter Peruzzotti , Charles John Sih
发明人： Warren Dexter Woessner , Henry Clifford Arndt , William Gerard Biddlecom , George Peter Peruzzotti , Charles John Sih
IPC分类号： C07C405/00 , C07C61/38 , C07C65/14 , C07C65/22 , C07C69/74
CPC分类号： C07C405/00
摘要： 11-Substituted-11-desoxy-PGE and -PGF analogues, in which the 11-substituent may be phenyl, (substituted)phenyl, cycloalkyl, spiroalkyl, branched or linear alkyl and alkenyl, and 3-hydroxy-alkenyl, stimulate smooth muscle.
摘要翻译： 11-取代的-11-脱氧-PGE和-PGF类似物，其中11个取代基可以是苯基，（取代的）苯基，环烷基，螺烷基，支链或直链的烷基和烯基和3-羟基 - 链烯基，刺激平滑肌 。
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公开(公告)号：US4098823A
公开(公告)日：1978-07-04
申请号：US758124
申请日：1977-01-10
IPC分类号： C07C33/44 , C07C405/00 , C07D309/12 , C07C49/46
CPC分类号： C07D309/12 , C07C33/44 , C07C405/00
摘要： Novel monospiroalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacalogical properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
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