公开(公告)号：US20210349061A1

公开(公告)日：2021-11-11

申请号：US17308637

申请日：2021-05-05

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Kevin Wyndham ,  Bonnie Alden ,  Dominic Foley ,  David Morrissey

IPC: G01N30/56 ,  G01N30/88 ,  G01N30/72

Abstract: The present disclosure relates to the use of vapor deposition coated flow paths for improved chromatography and sample analysis using liquid chromatography-mass spectrometry (LC/MS) or liquid chromatography-optical detection (LC/UV). More specifically, this technology relates to separating and quantitation of analytes (e.g., phospho prodrugs and its phosphorylated metabolites) from a sample matrix (e.g., mammalian blood, plasma) using chromatographic devices and fluidic systems having coated flow paths. The LC-MS or LC-UV techniques provide improved recovery, peak shape and dynamic range in the analysis of the prodrug and its metabolites.