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公开(公告)号：US12121829B2
公开(公告)日：2024-10-22
申请号：US16800928
申请日：2020-02-25
CPC分类号： B01D15/22 , C08J7/065 , G01N30/32 , G01N30/6026 , G01N30/603 , G01N30/6052 , G01N2030/027 , G01N2030/324
摘要： The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.
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2.发明公开公开(公告)号：US20240335830A1
公开(公告)日：2024-10-10
申请号：US18749930
申请日：2024-06-21
CPC分类号： B01L3/5023 , B01D15/3809 , B01D15/424 , B01L2200/0631 , B01L2200/0668 , B01L2300/0681 , B01L2300/069 , B01L2400/0409 , B01L2400/0433
摘要： A sample preparation device is provided for enriching a component of a sample. The sample preparation device includes a surface in fluid communication with the sample, an alkylsilyl coating disposed on the surface, and an affinity ligand or an enzyme covalently bonded to the alkylsilyl coating.
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公开(公告)号：US20240092959A1
公开(公告)日：2024-03-21
申请号：US18174309
申请日：2023-02-24
IPC分类号： C08F283/06
CPC分类号： C08F283/06
摘要： The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a bonding material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
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4.发明公开公开(公告)号：US20230364585A1
公开(公告)日：2023-11-16
申请号：US18144514
申请日：2023-05-08
发明人： Matthew A. Lauber , Catalin Doneanu , Weibin Chen , Ying Qing Yu , Jennifer M. Nguyen , Fabrice Gritti , Martin Gilar
IPC分类号： B01J20/288 , B01J20/32 , B01J20/10 , B01J20/28
CPC分类号： B01J20/288 , B01J20/103 , B01J20/28004 , B01J20/3204 , B01J2220/54
摘要： The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into a chromatographic column that is packed with a porous sorbent having a pore size that substantially excludes the polynucleotides from the sorbent. This restricted access to the sorbent allows separation of large polynucleotides from each other and from smaller molecular weight impurities.
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公开(公告)号：US20220412963A1
公开(公告)日：2022-12-29
申请号：US17338022
申请日：2021-06-03
IPC分类号： G01N33/533 , C07D215/48
摘要： Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
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公开(公告)号：US20220082532A1
公开(公告)日：2022-03-17
申请号：US17471449
申请日：2021-09-10
发明人： Amit Patel , Moon Chul Jung , Susan Rzewuski , Thomas H. Walter , Matthew A. Lauber , Kevin Wyndham , Mathew DeLano , Jennifer Simeone
摘要： The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.
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公开(公告)号：US20210388022A1
公开(公告)日：2021-12-16
申请号：US17314748
申请日：2021-05-07
发明人： Xiaoxiao Liu , Wenjing Li , Matthew A. Lauber
IPC分类号： C07K1/113 , C07C279/04 , C12Q1/37 , C07D487/04
摘要： The present disclosure relates to a system for a composition for protein denaturation. The composition includes a non-nucleophilic denaturant comprising a substituted guanidine, wherein the denaturant has a pKa value greater than about 10, and wherein the concentration of the substituted guanidine is less than 250 mM.
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公开(公告)号：US20210349061A1
公开(公告)日：2021-11-11
申请号：US17308637
申请日：2021-05-05
摘要： The present disclosure relates to the use of vapor deposition coated flow paths for improved chromatography and sample analysis using liquid chromatography-mass spectrometry (LC/MS) or liquid chromatography-optical detection (LC/UV). More specifically, this technology relates to separating and quantitation of analytes (e.g., phospho prodrugs and its phosphorylated metabolites) from a sample matrix (e.g., mammalian blood, plasma) using chromatographic devices and fluidic systems having coated flow paths. The LC-MS or LC-UV techniques provide improved recovery, peak shape and dynamic range in the analysis of the prodrug and its metabolites.
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公开(公告)号：US20210347814A1
公开(公告)日：2021-11-11
申请号：US17314541
申请日：2021-05-07
摘要： The present disclosure relates to a method of digesting a sample comprising protein, the method comprising: adding the sample to an apparatus containing a buffer and a solid support surface comprising a surface coating, wherein the surface coating immobilizes enzyme while reducing undesired interactions between the sample and the solid support surface; immobilizing enzymes on the surface coating for digestion of the protein of the sample; and heating the sample to complete a heat-assisted digestion of the protein.
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公开(公告)号：US20210255196A1
公开(公告)日：2021-08-19
申请号：US17151036
申请日：2021-01-15
发明人： Robert Birdsall , Jacob Kellett , Nilini Ranbaduge , Ying Qing Yu , Jennifer M. Nguyen , Matthew A. Lauber
IPC分类号： G01N33/68 , G01N30/72 , B01J20/281
摘要： The present disclosure discusses a method of separating a sample (e.g., peptide compound) including coating a flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating (e.g., organosilica coating) of the flow path. The applied coating can reduce peak tailing and increase analyte recovery for the sample of the chromatographic system.
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