公开(公告)号：US20250027911A1

公开(公告)日：2025-01-23

申请号：US18777771

申请日：2024-07-19

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Fabrice Gritti ,  Jason F. Hill ,  Sornanathan Meyyappan ,  Joseph D. Michienzi

IPC: G01N30/60 ,  G01N30/02

Abstract: A frit and a chromatography column that includes the frit are described. The frit is formed as a disk having a porosity, a radius and a thickness. The disk has a variation in porosity, thickness, or both porosity and thickness along a radial direction. A flow of a liquid through an outer region of the disk is advanced at an outlet end of the disk relative to a flow of the liquid through an inner region of the disk. The frit is configured to be disposed at one end of a column bed of a liquid chromatography column where the advance in the flow in the outer region relative to the flow in the inner region is predetermined to at least partially compensate for a radial variation in the linear velocity of the flow through the column bed.