公开(公告)号：US20190062705A1

公开(公告)日：2019-02-28

申请号：US16118090

申请日：2018-08-30

申请人： WAYNE STATE UNIVERSITY

发明人： Kang Chen ,  Bo Pei

IPC分类号： C12N5/0781 ,  C07K16/06 ,  C12N15/62 ,  C07K14/57 ,  C07K14/705 ,  C07K14/54

摘要： Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

公开(公告)号：US11001804B2

公开(公告)日：2021-05-11

申请号：US16118090

申请日：2018-08-30

申请人： WAYNE STATE UNIVERSITY

发明人： Kang Chen ,  Bo Pei

IPC分类号： C12N5/0781 ,  C07K14/54 ,  C07K14/495 ,  C07K16/06 ,  C12N15/62 ,  C07K14/705 ,  C07K14/57 ,  C07K14/47

摘要： Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

公开(公告)号：US12065672B2

公开(公告)日：2024-08-20

申请号：US17224047

申请日：2021-04-06

申请人： Wayne State University

发明人： Kang Chen ,  Bo Pei

IPC分类号： C12N5/0781 ,  C07K14/47 ,  C07K14/495 ,  C07K14/54 ,  C07K14/57 ,  C07K14/705 ,  C07K16/06 ,  C12N15/62

CPC分类号： C12N5/0635 ,  C07K14/4702 ,  C07K14/495 ,  C07K14/5406 ,  C07K14/57 ,  C07K14/70578 ,  C07K16/06 ,  C07K16/065 ,  C12N15/62 ,  C07K2317/565 ,  C07K2319/21 ,  C07K2319/41 ,  C07K2319/43 ,  C12N2310/20

摘要： Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.

公开(公告)号：US20210317405A1

公开(公告)日：2021-10-14

申请号：US17224047

申请日：2021-04-06

申请人： Wayne State University

发明人： Kang Chen ,  Bo Pei

IPC分类号： C12N5/0781 ,  C07K16/06 ,  C12N15/62 ,  C07K14/705 ,  C07K14/54 ,  C07K14/57 ,  C07K14/495 ,  C07K14/47

摘要： Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.