公开(公告)号：US20200179500A1

公开(公告)日：2020-06-11

申请号：US16704679

申请日：2019-12-05

Applicant: Wayne State University

Inventor： Wei-Zen Wei ,  Richard F. Jones ,  Joyce Reyes ,  Heather Gibson

IPC: A61K39/00 ,  A61K39/39 ,  A61K35/76

Abstract: Only limited success has been previously achieved from cancer vaccines targeting unmodified tumor-associated self-antigens and new compositions and methods are needed. Immunogenic compositions and methods of use thereof are provided according to the present disclosure which include a protein effective to stimulate immune activity against a tumor-associated self-antigen, or a variant thereof which is a tumor-associated self-antigen.

公开(公告)号：US20240252659A1

公开(公告)日：2024-08-01

申请号：US18528165

申请日：2023-12-04

Applicant: Wayne State University

Inventor： Wei-Zen Wei ,  Richard F. Jones (Deceased) ,  Joyce Reyes ,  Heather Gibson

IPC: A61K47/58 ,  A61K31/337 ,  A61K35/76 ,  A61K38/28 ,  A61K39/00 ,  A61K39/39 ,  A61K47/54 ,  A61K47/69 ,  C07C227/16 ,  C07C229/22 ,  C07K16/28 ,  C08F120/36 ,  C08G81/02 ,  C12N15/86

CPC classification number: A61K47/58 ,  A61K31/337 ,  A61K35/76 ,  A61K38/28 ,  A61K39/001106 ,  A61K39/39 ,  A61K47/543 ,  A61K47/544 ,  A61K47/6909 ,  A61K47/6915 ,  A61K47/6921 ,  C07C227/16 ,  C07C229/22 ,  C08F120/36 ,  C08G81/027 ,  A61K39/001104 ,  A61K2039/585 ,  C07K16/2863 ,  C12N15/86

Abstract: Only limited success has been previously achieved from cancer vaccines targeting unmodified tumor-associated self-antigens and new compositions and methods are needed. Immunogenic compositions and methods of use thereof are provided according to the present disclosure which include a protein effective to stimulate immune activity against a tumor-associated self-antigen, or a variant thereof which is a tumor-associated self-antigen.

公开(公告)号：US10434152B2

公开(公告)日：2019-10-08

申请号：US15120621

申请日：2015-02-19

Applicant: Wayne State University

Inventor： Wei-Zen Wei ,  Heather Gibson ,  Richard Jones ,  Joyce Reyes

IPC: A61K39/00 ,  A61K39/39 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  G01N33/574

Abstract: Antigenic polypeptides of the growth factor receptor HER2, for breaking the tolerance of a host against self HER2. The antigenic polypeptides include HER2 polypeptides with single amino acid substitutions of lysine for glutamine, arginine for glutamine, or aspartic acid for asparagine. Gene expression constructs, vaccine compositions, and immunization methods including the substituted HER2 polypeptides. Methods for immunizing mammalian subjects with heterologous unsubstituted HER2 antigenic polypeptides, including polypeptides of feline and bear HER2. A diagnostic method of determining whether a mammalian subject is sufficiently immunocompetent to respond to immunotherapies directed at breaking tolerance to self HER2.