专利检索 ap:("Weidong Ye" OR "Jianyong Yuan" OR "Jingjing Nie" OR "Duanjun Xu" OR "Chaotian Chen") AND inv:"Duanjun Xu" 第 1 页

1.

发明授权
Crystalline form of entecavir, its preparation and the pharmaceutical composition and uses thereof 有权
标题翻译：恩替卡韦的结晶形式及其制备及其药物组合物及其用途

公开(公告)号：US08937076B2

公开(公告)日：2015-01-20

申请号：US12527215

申请日：2008-01-31

申请人： Weidong Ye , Jianyong Yuan , Jingjing Nie , Duanjun Xu , Chaotian Chen

发明人： Weidong Ye , Jianyong Yuan , Jingjing Nie , Duanjun Xu , Chaotian Chen

IPC分类号： A61K31/522 , C07D473/18

CPC分类号： C07D473/18

摘要： The present invention relates to a crystalline form of entecavir and its process for preparation, and provides a pharmaceutical composition comprising a therapeutically effective amount of the crystalline form of entecavir. Furthermore, the present invention also provides a use of the crystalline form of entecavir in preparation for a medicament for the treatment of hepatitis B viral infections. The present invention is beneficial toe preparations for pharmaceutical formulations and enhancements of its bioavailability.

摘要翻译： 本发明涉及恩替卡韦的结晶形式及其制备方法，并且提供包含治疗有效量的恩替卡韦结晶形式的药物组合物。此外，本发明还提供恩替卡韦的结晶形式用于制备用于治疗乙型肝炎病毒感染的药物的用途。本发明有益于药物制剂的制备和其生物利用度的提高。