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公开(公告)号：US07078403B1
公开(公告)日：2006-07-18
申请号：US10018963
申请日：2000-06-16
申请人： Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
发明人： Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
IPC分类号： A61K31/53
CPC分类号： C07D401/04 , C07D237/20 , C07D237/22 , C07D261/08 , C07D403/04 , C07D417/14
摘要： Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as well as other compounds of the general formula Het-A-Alk-W-Ar-C(X2)═NO-X2 where Het, A, W and Ar are also defined herein. These compounds are useful in treating picornavirus infections in mammals. Novel intermediates of these compounds, as well as pharmaceutical compositions and methods of use, are also disclosed herein.
摘要翻译： 本文公开了式II的化合物：其中Alk，Z，X 1，X 2，R 1，R 10， 本文定义的本文及其盐及其药学上可接受的衍生物，以及通式Het-A-Alk-W-Ar-C（X
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公开(公告)号：US07205333B2
公开(公告)日：2007-04-17
申请号：US10363988
申请日：2001-09-07
申请人： Wen-Yang Wu , Michael Dennis Dowle , Betty Jin , Simon John Fawcett Macdonald , Andrew McMurtrie Mason , Darryl McConnell , Keith Watson
发明人： Wen-Yang Wu , Michael Dennis Dowle , Betty Jin , Simon John Fawcett Macdonald , Andrew McMurtrie Mason , Darryl McConnell , Keith Watson
IPC分类号： A61K31/35 , C07D307/02
CPC分类号： C07D407/14 , C07D309/28 , C07D493/04 , C12Q1/04
摘要： The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which binds to the active site of influenza virus neuraminidase, but is not cleaved by the neuraminidase. The invention also relates to processes for the preparation of the multimeric compound defined above, pharmaceutical compositions containing them or methods for the treatment and/or prophylaxis of a viral infection involving them.
摘要翻译： 本发明涉及多分子化合物或其药学上可接受的盐或衍生物，其包含与间隔基或连接基团连接的三个或更多个神经氨酸酶结合基团，其中神经氨酸酶结合基团是结合流感病毒活性位点的化合物 病毒神经氨酸酶，但不被神经氨酸酶切割。 本发明还涉及制备上述多聚化合物的方法，含有它们的药物组合物或用于治疗和/或预防涉及它们的病毒感染的方法。
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公开(公告)号：US20130005736A1
公开(公告)日：2013-01-03
申请号：US13540865
申请日：2012-07-03
IPC分类号： A61K31/501 , A61P31/14
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
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公开(公告)号：US08217171B2
公开(公告)日：2012-07-10
申请号：US13100931
申请日：2011-05-04
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US08624025B2
公开(公告)日：2014-01-07
申请号：US13540865
申请日：2012-07-03
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新中间体。
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公开(公告)号：US07579465B2
公开(公告)日：2009-08-25
申请号：US11559242
申请日：2006-11-13
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4523 , A61K31/53 , A61K31/506 , A61P31/12
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新中间体。
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公开(公告)号：US20070149531A1
公开(公告)日：2007-06-28
申请号：US11559253
申请日：2006-11-13
IPC分类号： A61K31/53 , A61K31/501 , A61K31/497 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US20090030000A1
公开(公告)日：2009-01-29
申请号：US12113718
申请日：2008-05-01
IPC分类号： C07D413/14 , C07D413/12 , C07D417/14 , C07D401/14 , A61K31/501 , A61K31/496 , A61K31/423 , A61K31/445 , A61K31/502 , A61P31/12
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新中间体。
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公开(公告)号：US20110212966A1
公开(公告)日：2011-09-01
申请号：US13100931
申请日：2011-05-04
IPC分类号： A61K31/53 , C07D413/14 , A61K31/501 , A61P31/16 , A61K31/454
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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公开(公告)号：US07951955B2
公开(公告)日：2011-05-31
申请号：US12113718
申请日：2008-05-01
IPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/16
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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