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    System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
    1.
    发明授权
    System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing 有权
    用于制造控制释放剂型的系统，例如通过三维印刷制造的零级释放曲线剂型

    公开(公告)号：US07300668B2

    公开(公告)日：2007-11-27

    申请号：US10284039

    申请日：2002-10-29

    申请人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24

    CPC分类号： A61K9/2893 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2095 ,  B33Y70/00 ,  B33Y80/00

    摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.

    摘要翻译： 本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。 本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。 根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。 本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。 本发明还包括设计这种剂型的方法。 可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。

    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
    2.
    发明授权
    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 有权
    用于单轴压缩制品的系统和方法，例如三维印刷的剂型

    公开(公告)号：US07931914B2

    公开(公告)日：2011-04-26

    申请号：US10284430

    申请日：2002-10-29

    申请人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61F13/00

    CPC分类号： A61K9/20 ,  A61J3/10 ,  A61K9/2095 ,  B29C64/00 ,  B29C64/165 ,  B29C67/0051 ,  B29C67/0081 ,  B29L2031/753 ,  B33Y70/00 ,  B33Y80/00

    摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.

    摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。