公开(公告)号：US07078550B2

公开(公告)日：2006-07-18

申请号：US10466460

申请日：2002-01-10

申请人： Werner Hölzl ,  Wolfgang Haap ,  Jürgen Koppold

发明人： Werner Hölzl ,  Wolfgang Haap ,  Jürgen Koppold

IPC分类号： C07F7/04

CPC分类号： C07F7/0838 ,  C07F7/081

摘要： There are described silanyl phenols and naphthols of formula (1a) or (1b), wherein R1 is hydrogen; halogen; hydroxy; C1–C20alkyl; C3–C12cycloalkyl; C1–C20alkoxy; trifluoromethyl; pentafluoroethyl; mono- or di-C1–C5alkylamino; hydroxy-C1–C5alkyl; or phenyl, phenyl-C1–C20alkyl, phenoxy, phenyl-C1–C20alkoxy, naphthyl or naphthyl-C1–C20alkyl each unsubstituted or substituted by C1–C5alkyl, C3–C12cycloalkyl, C1–C5alkoxy, C3–C12cycloalkoxy, halogen, oxo, carboxy, carboxy-C1–C7alkyl ester, carboxy-C3–C12cycloalkyl ester, cyano, trifluoromethyl, pentafluoroethyl, amino, N,N-mono- or di-C1–C20alkylamino or by nitro; R2, R3 and R4 are each independently of the others hydrogen; C1–C20alkyl; or C3–C12-cycloalkyl; R5, R6 and R7 are each independently of the others C1–C20alkyl, C5–C10aryl, C1–C20alkoxy, phenyl-C1–C20alkyl, phenyl-C1–C20alkoxy, C2–C5alkenyl, —O—Si—(C1–C5alkyl)3; or O—Si—(C1–C5alkyl)2-O—Si(C1–C5alkyl)3 and n is 0 or 1. The compounds exhibit a pronounced activity against Gram positive and Gram negative bacteria, and also against yeasts and moulds

公开(公告)号：US06743940B2

公开(公告)日：2004-06-01

申请号：US10016542

申请日：2001-12-13

申请人： Werner Hölzl ,  Wolfgang Haap ,  Jürgen Koppold ,  Dietmar Ochs ,  Karin Petzold ,  Marcel Schnyder

发明人： Werner Hölzl ,  Wolfgang Haap ,  Jürgen Koppold ,  Dietmar Ochs ,  Karin Petzold ,  Marcel Schnyder

IPC分类号： C07C22900

CPC分类号： C07C229/30

摘要： There are described 4-aminobut-2-ynecarboxylic acid derivatives of formula wherein R1 and R2 are each independently of the other hydrogen, C1-C20alkyl; C3-C12cycloalkyl; unsubstituted or C1-C5alkyl-, C3-C12cycloalkyl-, C1-C5alkoxy-, C3-C12cycloalkoxy-, halo-, oxo-, carboxy-, carboxy-C1-C7alkyl ester-, carboxy-C3-C12cycloalkyl ester-, cyano-, trifluoromethyl-, pentafluoroethyl-, amino-, N,N-mono- or di-C1-C20alkylamino- or nitro-substituted phenyl, phenyl-C1-C5alkyl, naphthyl and naphthyl-C1-C5alkyl; and R3 is C1-C20alkyl; C3-C12cycloalkyl. The compounds exhibit a pronounced activity against gram-positive and gram-negative bacteria, and also against yeasts and moulds.

摘要翻译： 描述了通式为R 1的4-氨基丁-2-炔酸衍生物，R 2各自独立地为氢，C 1 -C 20烷基; C 3 -C 12环烷基; 未取代的或C 1 -C 5烷基 - ，C 3 -C 12环烷基 - ，C 1 -C 5烷氧基 - ，C 3 -C 12环烷氧基 - ，卤代 - ，氧代 - ，羧基 - ，羧基-C 1 -C 7烷基酯 - ，羧基-C 3 -C 12环烷基酯 - 氰基 - 三氟甲基 - ，五氟乙基 - ，氨基 - ，N，N-单或二-C 1 -C 20烷基氨基或硝基取代的苯基，苯基-C 1 -C 5烷基，萘基和萘基-C 1 -C 5烷基; 和R 3是C 1 -C 20烷基; C3-C12环烷基。化合物对革兰氏阳性和革兰氏阴性细菌以及酵母和霉菌都表现出明显的活性。