公开(公告)号：US20240101584A1

公开(公告)日：2024-03-28

申请号：US18266936

申请日：2022-01-29

申请人： Westlake University

发明人： Dan YANG ,  Ming Kwan WONG

IPC分类号： C07F9/655 ,  A61K45/06 ,  A61P35/00 ,  C07D323/04 ,  C07D405/12 ,  C07D407/12 ,  C07H13/12

CPC分类号： C07F9/65522 ,  A61K45/06 ,  A61P35/00 ,  C07D323/04 ,  C07D405/12 ,  C07D407/12 ,  C07H13/12

摘要： 1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.