-
1.发明授权Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation 有权使用UTRN mRNA翻译调节法筛选化合物治疗肌营养不良的方法公开(公告)号：US08283115B1
公开(公告)日：2012-10-09
申请号：US12143705
申请日：2008-06-20
申请人： Westley J Friesen , Nikolai Naryshkin , Meenal Patel , Charles Romfo , Ellen Welch , Yuki Tomizawa , Jin Zhuo
发明人： Westley J Friesen , Nikolai Naryshkin , Meenal Patel , Charles Romfo , Ellen Welch , Yuki Tomizawa , Jin Zhuo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C07K14/70546 , C12N15/1138 , C12N15/8209 , C12Q1/6883 , C12Q2600/136 , G01N33/5023
摘要： The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of muscular dystrophy (MD), or a form thereof, in which said compounds increase the post-transcriptional expression of a target gene (i.e., mIGF1, ITGA7, or UTRN).
摘要翻译： 本发明提供用于鉴定和验证用于治疗肌营养不良（MD）或其形式的化合物的化合物和测定法，其中所述化合物增加靶基因的转录后表达（即mIGF1， ITGA7或UTRN）。
-
2.发明申请Methods for identifying small molecules that modulate premature translation termination and nonsense mrna decay 有权用于鉴定调节过早翻译终止和废话mrna衰变的小分子的方法公开(公告)号：US20050233327A1
公开(公告)日：2005-10-20
申请号：US10519243
申请日：2003-06-23
申请人： Ellen Welch , Jin Zhuo
发明人： Ellen Welch , Jin Zhuo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897
摘要： The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that modulate the post-transcriptional expression of any gene with a premature translation stop codon. The invention particularly relates to using any gene encoding a premature stop codon to identify compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay. A compound that modulates premature translation termination and/or nonsense-mediated mRNA decay of a target gene is identified using standard methods known in the art to measure changes in translation or mRNA stability of the gene product or mRNA of the gene with the premature stop codon. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
摘要翻译： 本发明涉及通过筛选和鉴定调节具有过早翻译终止密码子的任何基因的转录后表达的化合物来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物的方法。 本发明特别涉及使用编码过早终止密码子的任何基因来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物。 使用本领域已知的标准方法鉴定调节前体转录终止和/或无义介导的mRNA基因的衰老的化合物，以测量基因产物或基因mRNA的mRNA稳定性的变化，所述基因产物或mRNA的早期终止密码子 。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单，灵敏的测定。
-
3.发明授权Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay 有权用于鉴定调节过早翻译终止和无义mRNA衰变的小分子的方法公开(公告)号：US07291461B2
公开(公告)日：2007-11-06
申请号：US10519243
申请日：2003-06-23
申请人： Ellen Welch , Jin Zhuo
发明人： Ellen Welch , Jin Zhuo
CPC分类号： C12Q1/6897
摘要： The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that modulate the post-transcriptional expression of any gene with a premature translation stop codon. The invention particularly relates to using any gene encoding a premature stop codon to identify compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay. A compound that modulates premature translation termination and/or nonsense-mediated mRNA decay of a target gene is identified using standard methods known in the art to measure changes in translation or mRNA stability of the gene product or mRNA of the gene with the premature stop codon. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
摘要翻译： 本发明涉及通过筛选和鉴定调节具有过早翻译终止密码子的任何基因的转录后表达的化合物来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物的方法。 本发明特别涉及使用编码过早终止密码子的任何基因来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物。 使用本领域已知的标准方法鉴定调节前体转录终止和/或无义介导的mRNA基因的衰老的化合物，以测量基因产物或基因mRNA的mRNA稳定性的变化，所述基因产物或mRNA的早期终止密码子 。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单，灵敏的测定。
-
-
搜索结果
3 条记录 (耗时 0.04 秒)
