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1.发明授权公开(公告)号：US08350055B2
公开(公告)日：2013-01-08
申请号：US12839612
申请日：2010-07-20
申请人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet, legal representative , Liliane Unger , Wilfried Lubisch
发明人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Liliane Unger , Wilfried Lubisch
IPC分类号： C07D411/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6, and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
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2.发明授权Substituted oxindole derivatives, medicaments containing said derivatives and use thereof 有权取代的羟吲哚衍生物，含有所述衍生物的药物及其用途公开(公告)号：US08044079B2
公开(公告)日：2011-10-25
申请号：US12095594
申请日：2006-12-01
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4525 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivative of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in Claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防 和/或加压素依赖性疾病的治疗。
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公开(公告)号：US07951807B2
公开(公告)日：2011-05-31
申请号：US11632462
申请日：2005-07-13
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
IPC分类号： A61K31/404 , A61K31/454 , C07D209/34 , C07D401/12
CPC分类号： C07D401/12 , C07D209/34
摘要： The present invention relates to novel oxindole derivatives of the general formula (I), wherein the substituents A, B, R1, R2 and R3 are as defined in Claim 1, and medicaments containing the same for the prophylaxis and/or treatment of vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基A，B，R 1，R 2和R 3如权利要求1所定义，以及含有其的用于预防和/或治疗加压素 - 依赖性或催产素依赖性疾病。
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4.发明申请公开(公告)号：US20110071156A1
公开(公告)日：2011-03-24
申请号：US12839612
申请日：2010-07-20
申请人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Lubisch
发明人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Lubisch
IPC分类号： A61K31/501 , C07D417/14 , A61K31/428 , C07D403/14 , A61K31/513 , C07D401/14 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61K31/4709 , A61K31/4184 , A61K31/405 , A61K31/496 , A61P25/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6, and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
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5.发明申请Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing Them 有权杂芳基取代的1,3-二氢吲哚-2-酮衍生物和含有它们的药物公开(公告)号：US20070185126A1
公开(公告)日：2007-08-09
申请号：US10574211
申请日：2004-09-30
申请人： Wilfried Lubisch , Wilfried Hornberger , Thorsten Oost , Daryl Sauer , Liliane Unger , Wolfgang Wernet , Herve Geneste
发明人： Wilfried Lubisch , Wilfried Hornberger , Thorsten Oost , Daryl Sauer , Liliane Unger , Wolfgang Wernet , Herve Geneste
IPC分类号： A61K31/506 , A61K31/404 , C07D401/14 , C07D409/04 , C07D413/14 , C07D417/14 , A61K31/501 , A61K31/4709
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5 R6 and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译： 本发明涉及式（I）的新的1,3-二氢吲哚-2-酮（羟吲哚）衍生物，其中A，R 3，R 4，R 4， 根据权利要求1定义5,6和7和R 7以及含有它们用于治疗疾病的药物。 特别地，新型羟基吲哚衍生物可用于控制和/或预防各种加压素依赖性或催产素依赖性疾病。
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6.发明授权Substituted oxindole derivatives, medicaments containing said derivatives and use thereof 有权取代的羟吲哚衍生物，含有所述衍生物的药物及其用途公开(公告)号：US09006276B2
公开(公告)日：2015-04-14
申请号：US13243166
申请日：2011-09-23
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D401/12 , A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4525 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防 和/或加压素依赖性疾病的治疗。
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7.发明申请SUBSTITUTED OXINDOLE DERIVATIVES AND THEIR USE AS VASOPRESSIN RECEPTOR LIGANDS 有权取代的氧化衍生物及其作为血管收缩素受体配体使用公开(公告)号：US20120322809A1
公开(公告)日：2012-12-20
申请号：US13590261
申请日：2012-08-21
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
IPC分类号： C07D409/14 , A61K31/4545 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/00 , A61P1/04 , A61K31/496 , A61P9/12
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与包含它们的药物及其用于预防和/或治疗依赖于加压素的疾病的用途。
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8.发明申请SUBSTITUTED OXINDOLE DERIVATIVES AND THEIR USE AS VASOPRESSIN RECEPTOR LIGANDS 有权取代的氧化衍生物及其作为血管收缩素受体配体使用公开(公告)号：US20110124658A1
公开(公告)日：2011-05-26
申请号：US12521713
申请日：2007-12-28
申请人： Astrid Netz , Thorsten Oost , Herve' Geneste , Wilfried Martin Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
发明人： Astrid Netz , Thorsten Oost , Herve' Geneste , Wilfried Martin Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , C07D401/14 , A61K31/4545 , A61P9/12 , A61P3/10 , A61P13/00 , A61P7/02 , A61P13/12 , A61P3/00 , A61P1/00 , A61P1/16 , A61P9/10 , A61P25/22 , A61P25/18 , A61P25/30
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与包含它们的药物及其用于预防和/或治疗依赖于加压素的疾病的用途。
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9.发明申请Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof 有权取代的羟吲哚衍生物，含有后者的药物及其用途公开(公告)号：US20090186904A1
公开(公告)日：2009-07-23
申请号：US11886729
申请日：2006-03-23
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste
IPC分类号： A61K31/496 , C07D401/14 , A61P25/28
CPC分类号： C07D403/12 , C07D401/12 , C07D417/12
摘要： The invention relates to novel oxindole derivatives of general formula (I), in which the substituents A, B, R1, R2 and R3 are defined as cited in claim 1, to medicaments containing said derivatives and to the use of the latter for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基A，B，R 1，R 2和R 3如权利要求1中所定义，含有所述衍生物的药物及其用于预防的药物 和/或加压素依赖性和/或催产素依赖性疾病的治疗。
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公开(公告)号：US20090005397A1
公开(公告)日：2009-01-01
申请号：US11632462
申请日：2005-07-13
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
IPC分类号： A61K31/496 , C07D401/14
CPC分类号： C07D401/12 , C07D209/34
摘要： The invention relates to novel oxindol derivatives of general formula (1) wherein the substituents A, B, R1, R2 and R3 have the designations cited in patent claim 1, and to medicaments containing said derivatives for the prophylaxis and/or treatment of vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（1）的新型羟吲哚衍生物，其中取代基A，B，R 1，R 2和R 3具有专利权利要求1中引用的名称，以及含有用于预防和/或治疗加压素 - 依赖性或催产素依赖性疾病。
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