公开(公告)号：US06639067B1

公开(公告)日：2003-10-28

申请号：US09786716

申请日：2001-09-27

申请人： Willard C. Brinegar ,  Michael Wohlers ,  Michael A. Hubbard ,  Edward G. Zey ,  George Kvakovszky ,  Thomas H. Shockley ,  Rainer Roesky ,  Uwe Dingerdissen ,  Werner Kind

发明人： Willard C. Brinegar ,  Michael Wohlers ,  Michael A. Hubbard ,  Edward G. Zey ,  George Kvakovszky ,  Thomas H. Shockley ,  Rainer Roesky ,  Uwe Dingerdissen ,  Werner Kind

IPC分类号： C07G1700

CPC分类号： C07D493/04 ,  C07D307/20 ,  C08G63/672

摘要： A process is described for continuous production of anhydrosugar alcohol by continuous introducing of sugar alcohols and/or monoanhydrosugar alcohols into a reaction vessel and dehydration in the presence of an acid catalyst and solvent in which the resultant reaction product is soluble. Water and the solvent having the dissolved reaction product are each cointinuously removed from the reaction vessel. The reaction product is separated from the removed solvent and the product is optionally purified to a purity of 99.0% the solvent is recycled in the reaction vessel.

摘要翻译： 描述了通过将糖醇和/或单乙二醇糖连续引入反应容器中并在酸催化剂和其中所得反应产物可溶的溶剂的存在下进行脱水来连续生产脱水葡萄糖醇的方法。 水和具有溶解的反应产物的溶剂各自从反应容器中连续地除去。 将反应产物与去除的溶剂分离，任选地将产物纯化至99.0％的纯度，将溶剂在反应容器中再循环。

公开(公告)号：US06670033B1

公开(公告)日：2003-12-30

申请号：US09857574

申请日：2001-11-27

申请人： Michael A. Hubbard ,  Michael Wohlers ,  Helmut B. Witteler ,  Edward G. Zey ,  George Kvakovszky ,  Thomas H. Shockley ,  Larry F. Charbonneau ,  Norbert Kohle ,  Jochen Rieth

发明人： Michael A. Hubbard ,  Michael Wohlers ,  Helmut B. Witteler ,  Edward G. Zey ,  George Kvakovszky ,  Thomas H. Shockley ,  Larry F. Charbonneau ,  Norbert Kohle ,  Jochen Rieth

IPC分类号： D02G300

CPC分类号： C08G63/672 ,  Y10T428/29 ,  Y10T428/2913

摘要： A process for the formation of a purified anhydrosugar alcohol is disclosed, whereby the resultant purified anhydrosugar alcohol has a purity of at least 99.8% and is substantially colorless. The anhydrosugar alcohol is purified by distillation, recrystallization from methanol, ethanol or ethylene glycol, melt recrystallization, or a combination thereof. Preferably, the purification is by distillation followed by recrystallization from methanol, ethanol or ethylene glycol. A test for determining the purity of the anhydrosugar alcohol is disclosed, wherein the color of the anhydrosugar alcohol after annealing at a temperature of at least 260° C. for at least four hours is examined. Alternatively, purity can be determined by examination of ultraviolet (UV) transmittance of the purified anhydrosugar alcohol at various wavelengths. The purified anhydrosugar alcohol may be incorporated into a polymer such as a polyester, which may in turn be used to form such articles of manufacturing as containers, optical disks, fibers, sheets and films.

摘要翻译： 公开了形成纯化的脱水葡萄糖醇的方法，由此得到的纯化的脱水葡萄糖醇的纯度至少为99.8％，基本上是无色的。 通过蒸馏纯化脱水葡萄糖醇，从甲醇，乙醇或乙二醇中重结晶，熔融重结晶或其组合。 优选地，通过蒸馏进行纯化，然后从甲醇，乙醇或乙二醇中重结晶。 公开了用于测定脱水葡萄糖醇纯度的试验，其中在至少260℃的温度下退火至少4小时后的脱水葡萄糖醇的颜色被检查。 或者，可以通过检查各种波长的纯化的脱水葡萄糖醇的紫外线（UV）透射率来确定纯度。 纯化的脱水葡萄糖醇可以掺入聚合物如聚酯中，聚酯可以依次用于形成容器，光盘，纤维，片和薄膜等制造品。

公开(公告)号：US5300301A

公开(公告)日：1994-04-05

申请号：US984606

申请日：1992-12-02

申请人： Michael B. Lakin ,  Thomas H. Shockley ,  Edward G. Zey

发明人： Michael B. Lakin ,  Thomas H. Shockley ,  Edward G. Zey

IPC分类号： A61K9/20 ,  A61K31/19 ,  A61K9/14

CPC分类号： A61K9/20 ,  A61K31/19

摘要： Ibuprofen is isolated from tablets or other solids by dissolving the ibuprofen in an alkane or cycloalkane solvent, filtering off undissolved solid, and stripping the solvent from the ibuprofen by evaporation or by recrystallization at low temperatures.

摘要翻译： 通过将布洛芬溶解在烷烃或环烷烃溶剂中，滤出未溶解的固体，并通过蒸发或通​​过在低温下重结晶从布洛芬中汽提溶剂，将布洛芬与片剂或其它固体分离。

公开(公告)号：US5399760A

公开(公告)日：1995-03-21

申请号：US105724

申请日：1993-08-11

申请人： Edward G. Zey ,  Olan S. Fruchey ,  Thomas H. Shockley ,  Joe S. Trevino ,  B. Frank Wood ,  Daniel D. Lindley

发明人： Edward G. Zey ,  Olan S. Fruchey ,  Thomas H. Shockley ,  Joe S. Trevino ,  B. Frank Wood ,  Daniel D. Lindley

IPC分类号： C07C231/24 ,  C07C233/25 ,  C07C233/05

CPC分类号： C07C231/24

摘要： A method is provided for purifying crude N-acetyl-para-aminophenol (APAP) containing color bodies or their precursors, the method comprising: a) forming a solution of the crude APAP; and b) subsequently contacting the solution with substoichiometric quantifies of an acetylating agent for a sufficient period of time to convert said color bodies or their precursors to substantially non-color bodies/stable, colorless substances; said quantities of acetylating agent provided is such that substantially none of the APAP is converted to other compounds.

摘要翻译： 提供了一种纯化含有着色体或其前体的粗N-乙酰基对氨基苯酚（APAP）的方法，该方法包括：a）形成粗APAP溶液; 和b）随后将所述溶液与乙酰化剂的亚化学计量定量充分一段时间，以将所述着色体或其前体转化成基本上非色体/稳定的无色物质; 所提供的所述量的乙酰化剂使得基本上没有APAP转化为其它化合物。

公开(公告)号：US5151551A

公开(公告)日：1992-09-29

申请号：US579427

申请日：1990-09-06

申请人： Edward G. Zey ,  Thomas H. Shockley ,  Debra A. Ryan ,  Gary L. Moss

发明人： Edward G. Zey ,  Thomas H. Shockley ,  Debra A. Ryan ,  Gary L. Moss

IPC分类号： C07C51/43

CPC分类号： C07C51/43

摘要： This invention pertains to a method of purifying ibuprofen-comprising reaction product mixtures. The method of purification is based on crystallization of ibuprofen from a hydrocarbon solvent and the discovery that there are impurity complexes in the ibuprofen-comprising reaction product mixtures which cannot be removed by crystallization from a hydrocarbon solvent.The method of the invention includes at least one step in which the impurity complex in a first ibuprofen-comprising mixture is destabilized or broken up, followed by crystallization of the ibuprofen from a second solution or mixture comprising the first ibuprofen-comprising mixture, whereby the impurities which were previously complexed can then be removed from the ibuprofen by the crystallization of ibuprofen from a solvent.