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1.RADIOHALOIMATINIBS AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS 审中-公开
标题翻译: 放射性蛋白酶及其合成及其在PET成像中的应用公开(公告)号:US20110097268A1
公开(公告)日:2011-04-28
申请号:US12310333
申请日:2007-08-22
申请人: William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
发明人: William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
IPC分类号: A61K51/04 , C07D403/14 , A61P35/00
CPC分类号: A61K51/0491
摘要: We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
摘要翻译: 我们公开了合成放射性有机化合物的方法及其在癌细胞正电子发射断层扫描(PET)成像中的应用。
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2.Radiohaloimatinibs and Methods of Their Synthesis and Use in PET Imaging of Cancers 审中-公开
标题翻译: 他们合成和应用于PET成像的放射性卤代西他滨及其方法公开(公告)号:US20100322858A1
公开(公告)日:2010-12-23
申请号:US12438045
申请日:2007-08-22
申请人: William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
发明人: William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
CPC分类号: A61K51/0491
摘要: We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
摘要翻译: 我们公开了合成放射性有机化合物的方法及其在癌细胞正电子发射断层扫描(PET)成像中的应用。
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公开(公告)号:US20100144738A1
公开(公告)日:2010-06-10
申请号:US12439491
申请日:2007-08-29
申请人: William Bornmann , David Maxwell , Yunming Ying , Dongmei Han , Zhenghong Peng , Varsha Gandhi , Christine Stellrecht
发明人: William Bornmann , David Maxwell , Yunming Ying , Dongmei Han , Zhenghong Peng , Varsha Gandhi , Christine Stellrecht
IPC分类号: A61K31/522 , C07D473/00 , C07D487/04 , A61K31/5025 , A61P25/00
CPC分类号: C07D473/00 , C07D487/04
摘要: The present invention relates to compounds and methods use as inhibitors of c-Met. Certain compounds of the subject invention have the following structural formula (I). Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
摘要翻译: 本发明涉及用作c-Met抑制剂的化合物和方法。 本发明的某些化合物具有以下结构式(I)。 本发明的其它化合物具有本文定义的结构式。 本文还公开了包含本发明化合物的药物组合物。
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公开(公告)号:US20100144743A1
公开(公告)日:2010-06-10
申请号:US12439402
申请日:2007-09-04
申请人: William Bornmann , David Maxwell , Zhenghong Peng , Liwei Guo
发明人: William Bornmann , David Maxwell , Zhenghong Peng , Liwei Guo
IPC分类号: A61K31/506 , C07D239/42 , C07D403/10 , C07D471/04 , A61K31/4985 , A61P35/00
CPC分类号: A61K31/506
摘要: Compositions for inhibiting the catalytic activity of tyrosine kinases comprising compounds represented by Formulas (I), (II), and (III). Methods for treating proliferative diseases comprising administering a therapeutically effective amount of the above compositions.
摘要翻译: 用于抑制酪氨酸激酶的催化活性的组合物,其包含由式(I),(II)和(III)表示的化合物。 治疗增殖性疾病的方法包括施用治疗有效量的上述组合物。
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公开(公告)号:US20090281115A1
公开(公告)日:2009-11-12
申请号:US12307001
申请日:2007-06-29
申请人: William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
发明人: William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
IPC分类号: A61K31/496 , C07D471/04 , A61K31/437 , A61P35/00 , C12N9/99
CPC分类号: C07D471/04
摘要: Compounds and methods useful as inhibitors of c-Kit are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of c-Kit and processes for synthesizing these compounds are also described herein.
摘要翻译: 提出了可用作c-Kit抑制剂的化合物和方法。 含有这些化合物的药物组合物,使用这些化合物作为c-Kit抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号:US20110312992A1
公开(公告)日:2011-12-22
申请号:US13195825
申请日:2011-08-01
申请人: William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
发明人: William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
IPC分类号: A61K31/437 , A61P35/02 , A61P35/00 , C07D471/04 , C12N9/99
CPC分类号: C07D471/04
摘要: Compounds and methods useful as inhibitors of c-Kit are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of c-Kit and processes for synthesizing these compounds are also described herein.
摘要翻译: 提出了可用作c-Kit抑制剂的化合物和方法。 含有这些化合物的药物组合物,使用这些化合物作为c-Kit抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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