公开(公告)号：US08600479B2

公开(公告)日：2013-12-03

申请号：US12531808

申请日：2008-03-20

申请人： William D. Dalke ,  Kevin Lillehei ,  Thomas A. Jellison ,  Michael J. Gerber ,  James E. Matsuura ,  Stephen L Warren

发明人： William D. Dalke ,  Kevin Lillehei ,  Thomas A. Jellison ,  Michael J. Gerber ,  James E. Matsuura ,  Stephen L Warren

IPC分类号： A61B5/05

CPC分类号： A61K51/0491 ,  Y10T137/0402

摘要： A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum.

摘要翻译： 提供了一种导管系统，其适于在病人组织内的空间限定的植入物中导航，引导和植入导管或多个导管。 该系统可以包括组织导航系统和探针，以通知导航系统来引导导管在目标组织内的位置。 探针可以提供诸如光学视觉图像或超声图像的图像，或者可以提供无线电定位数据来引导导管放置。 导管提供包括生物活性剂的加压液体，例如可用于治疗癌症，例如123I-或125I-IUDR。 提供的系统和方法可用于局部晚期肿瘤的治疗，如脑，头颈部，食管，前列腺，卵巢，肝，胰腺，膀胱或直肠癌。