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    Methods and compositions for treating post-operative pain comprising clonidine
    1.
    发明授权
    Methods and compositions for treating post-operative pain comprising clonidine 有权
    用于治疗包括可乐定的术后疼痛的方法和组合物

    公开(公告)号：US08629172B2

    公开(公告)日：2014-01-14

    申请号：US12421144

    申请日：2009-04-09

    申请人： William F. McKay ,  Amira Wohabrebbi ,  Vanja Margareta King ,  Phillip Edward McDonald ,  Christopher M. Hobot ,  Troy Carter

    发明人： William F. McKay ,  Amira Wohabrebbi ,  Vanja Margareta King ,  Phillip Edward McDonald ,  Christopher M. Hobot ,  Troy Carter

    IPC分类号： A61K31/415

    CPC分类号： A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

    摘要： The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    摘要翻译： 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

    COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE PAIN USING BUPIVACAINE AND AN ANTI-ONFLAMMATORY AGENT
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE PAIN USING BUPIVACAINE AND AN ANTI-ONFLAMMATORY AGENT 审中-公开
    用BUPIVACAINE和抗炎药物治疗术后疼痛的组合物和方法

    公开(公告)号：US20100203102A1

    公开(公告)日：2010-08-12

    申请号：US12423201

    申请日：2009-04-14

    申请人： Amira Wohabrebbi

    发明人： Amira Wohabrebbi

    IPC分类号： A61F2/00 ,  A61K31/445

    CPC分类号： A61K45/06 ,  A61K9/0024 ,  A61K31/445 ,  A61K2300/00

    摘要： Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and an anti-inflammatory agent at or near a target site, one can alleviate or prevent pain while preventing undesirable levels of inflammation. This administration of bupivacaine and an anti-inflammatory agent is particularly useful following surgery.

    摘要翻译： 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和抗炎剂的组合，可以减轻或预防疼痛，同时防止不良的炎症水平。 布比卡因和抗炎剂的施用在手术后特别有用。