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公开(公告)号:US20120328706A1
公开(公告)日:2012-12-27
申请号:US13477832
申请日:2012-05-22
IPC分类号: A61K47/34 , A61K38/02 , A61K38/16 , A61K31/70 , A61K31/7088 , A61P29/00 , A61P27/16 , A61P27/02 , A61P1/00 , A61P19/06 , C08G69/48 , A61K9/14 , A61P31/00 , B82Y5/00
CPC分类号: A61K9/1075 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K47/34 , A61K47/48192 , A61K47/482 , A61K47/48207 , A61K47/59 , A61K47/593 , A61K47/595 , C07K16/2821 , C08L77/12 , C12N15/88 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要: The present invention provides biodegradable polymer particle delivery compositions based on polymers, such as polyester amide (PEA) and polyester urethane (PEUR) polymers, that contain amino acids in the polymer. The polymer particle delivery compositions can be formulated as a liquid dispersion of polymer particles with the bioactive agents dispersed in the particle or conjugated attached to polymer molecules or particle surfaces. The bioactive agents can include drugs, polypeptides, DNA and cells for cell-based therapies using particles sized for local, mucosal or circulatory delivery. Methods of treating a disease by administering to a subject the polymer particle delivery composition, which incorporates a bioactive agent suitable for treatment of the disease, or its symptoms, are also included.
摘要翻译: 本发明提供了基于在聚合物中含有氨基酸的聚合物如聚酯酰胺(PEA)和聚酯聚氨酯(PEUR)聚合物的可生物降解的聚合物颗粒递送组合物。 聚合物颗粒递送组合物可以配制成聚合物颗粒的液体分散体,其中分散在颗粒中的生物活性剂或缀合在聚合物分子或颗粒表面上。 生物活性剂可以包括药物,多肽,DNA和细胞用于基于细胞的疗法,使用尺寸适合局部,粘膜或循环递送的颗粒。 还包括通过向受试者施用包含适合于治疗该疾病的生物活性剂的聚合物颗粒递送组合物或其症状来治疗疾病的方法。