公开(公告)号：US06248358B1

公开(公告)日：2001-06-19

申请号：US09379310

申请日：1999-08-23

申请人： William J. Bologna ,  Howard L. Levine ,  Philippe Cartier ,  Dominique de Ziegler

发明人： William J. Bologna ,  Howard L. Levine ,  Philippe Cartier ,  Dominique de Ziegler

IPC分类号： A61K920

CPC分类号： A61K31/568 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059

摘要： A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).

摘要翻译： 生物粘附片剂，其中活性成分可以被保护免受水或周围环境的影响，从而保护其不受代谢或由水分，酶或pH影响引起的其它降解，并且仅以受控的速率使其生物可利用。 活性成分可以在制造过程中受到保护，并且更重要的是可以防止水分和直接的化脓性环境，直到患者施用片剂，然后仅以缓慢和受控的速率。 正是通过这种进行性水合过程，活性成分在给药后保持多个小时。 也是通过进行性水合的过程来实现控制和持续释放，因为只有作为片剂的水合（水性）级分的活性成分的那部分可用于吸收（生物可利用的）。

公开(公告)号：US5312411A

公开(公告)日：1994-05-17

申请号：US967161

申请日：1992-10-27

申请人： John K. Steele ,  Thomas A. Carls ,  David L. Evans ,  Carol D. Taylor ,  Philippe Cartier ,  James Andrews ,  William Kennedy

发明人： John K. Steele ,  Thomas A. Carls ,  David L. Evans ,  Carol D. Taylor ,  Philippe Cartier ,  James Andrews ,  William Kennedy

IPC分类号： A61B17/56 ,  A61B17/16 ,  A61B17/17 ,  A61B19/00 ,  A61F2/36 ,  A61F2/38

CPC分类号： A61B17/1675 ,  A61B17/1764 ,  A61F2/3859 ,  A61B2017/1602 ,  A61B2090/033 ,  A61F2002/3895

摘要： A surgical instrument for shaping the distal femur of a patient to receive a unicondylar prosthetic component includes a cutting guide body that carries a pair of cylindrically shaped openings in the guide body, each of the openings having a central longitudinal axis and the respective axes of the openings forming an acute angle. An annular bushing is removably received in a selected one of the cylindrical openings during a cutting of the distal femur. A bone cutting reamer registers with a central cylindrical opening in the bushing. The bone cutting reamer has an annular shoulder that abuts the top of the bushing to define the depth of cut. During use, the surgeon positions the cutting guide body over a diseased condyle of the patient's distal femur. The surgeon then sequentially places the bushing and its associated bone cutting reamer into one of the selected openings of the cutting guide body. After placing the bone cutting reamer in the second opening of the guide body, the surgeon has formed two overlapping circular cuts which form an elongated oval shaped and three-dimensionally convex surface for receiving the unicondylar prosthesis.

摘要翻译： 用于成形患者的远端股骨以接收单髁假体部件的手术器械包括切割引导体，该引导体在引导体中承载一对圆柱形的开口，每个开口具有中心纵向轴线和相应的轴线 开口形成锐角。 在切割远端股骨期间，环形衬套可移除地容纳在选定的一个圆柱形开口中。 骨切割铰刀与衬套中的中心圆柱形开口配准。 骨切割铰刀具有环形肩部，其邻接衬套的顶部以限定切割深度。 在使用期间，外科医生将切割引导体定位在患者的远端股骨的患病髁上。 然后外科医生顺序地将套管及其相关的骨切割扩孔器放置在切割引导体的所选择的开口之一中。 在将骨切割铰刀放置在引导体的第二开口中之后，外科医生已经形成两个重叠的圆形切口，其形成用于接纳单髁假体的细长的椭圆形和三维凸面。