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    Bioadhesive progressive hydration tablets and methods of making and using the same
    1.
    发明授权
    Bioadhesive progressive hydration tablets and methods of making and using the same 有权
    生物粘合剂逐步水合片及其制备和使用方法

    公开(公告)号：US06248358B1

    公开(公告)日：2001-06-19

    申请号：US09379310

    申请日：1999-08-23

    申请人： William J. Bologna ,  Howard L. Levine ,  Philippe Cartier ,  Dominique de Ziegler

    发明人： William J. Bologna ,  Howard L. Levine ,  Philippe Cartier ,  Dominique de Ziegler

    IPC分类号： A61K920

    CPC分类号： A61K31/568 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059

    摘要： A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).

    摘要翻译： 生物粘附片剂，其中活性成分可以被保护免受水或周围环境的影响，从而保护其不受代谢或由水分，酶或pH影响引起的其它降解，并且仅以受控的速率使其生物可利用。 活性成分可以在制造过程中受到保护，并且更重要的是可以防止水分和直接的化脓性环境，直到患者施用片剂，然后仅以缓慢和受控的速率。 正是通过这种进行性水合过程，活性成分在给药后保持多个小时。 也是通过进行性水合的过程来实现控制和持续释放，因为只有作为片剂的水合（水性）级分的活性成分的那部分可用于吸收（生物可利用的）。

    Progestin therapy for maintaining amenorrhea
    2.
    发明授权
    Progestin therapy for maintaining amenorrhea 失效
    孕激素治疗维持闭经

    公开(公告)号：US06306914B1

    公开(公告)日：2001-10-23

    申请号：US09170326

    申请日：1998-10-13

    申请人： Dominique de Ziegler ,  William J. Bologna ,  Howard L. Levine

    发明人： Dominique de Ziegler ,  William J. Bologna ,  Howard L. Levine

    IPC分类号： A01N2500

    CPC分类号： A61K31/57 ,  A61K9/0034 ,  A61K9/7023 ,  A61K47/32 ,  Y10S514/944 ,  A61K31/565 ,  A61K2300/00

    摘要： The present invention teaches that daily, cyclical vaginal delivery of progestin may be used to provide regular, predictable withdrawal bleeding during hormone replacement therapy. The present invention also teaches that constant administration of progestin in a water-insoluble, water-swellable cross-linked polycarboxylic acid polymer may be used to maintain amenorrhea. Either regimen is accompanied by a significant decrease in adverse side effects.

    摘要翻译： 本发明教导，孕激素替代治疗期间可以使用孕激素的每日周期性阴道分娩来提供规则的，可预测的撤出性出血。 本发明还教导了在水不溶性的水溶胀性交联聚羧酸聚合物中不断施用孕激素以维持闭经。 两种方案都伴随着副作用的显着降低。

    Progestin therapy for maintaining amenorrhea
    3.
    发明授权
    Progestin therapy for maintaining amenorrhea 失效
    孕激素治疗促进定期戒断出血

    公开(公告)号：US06593317B1

    公开(公告)日：2003-07-15

    申请号：US09833259

    申请日：2000-10-17

    申请人： Dominique de Ziegler ,  William J. Bologna ,  Howard L. Levine

    发明人： Dominique de Ziegler ,  William J. Bologna ,  Howard L. Levine

    IPC分类号： A61K3157

    CPC分类号： A61K31/57 ,  A61K9/0034 ,  A61K9/7023 ,  A61K47/32 ,  Y10S514/944 ,  A61K31/565 ,  A61K2300/00

    摘要： The present invention teaches that daily, cyclical vaginal delivery of progestin may be used to provide regular, predictable withdrawal bleeding during hormone replacement therapy. The present invention also teaches that constant administration of progestin in a water-insoluble, water-swellable cross-linked polycarboxylic acid polymer may be used to maintain amenorrhea. Either regimen is accompanied by a significant decrease in adverse side effects.

    摘要翻译： 本发明教导，孕激素替代治疗期间可以使用孕激素的每日周期性阴道分娩来提供规则的，可预测的撤出性出血。 本发明还教导了在水不溶性的水溶胀性交联聚羧酸聚合物中不断施用孕激素以维持闭经。 两种方案都伴随着副作用的显着降低。