公开(公告)号：US06939348B2

公开(公告)日：2005-09-06

申请号：US10679245

申请日：2003-10-02

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alegandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alegandro

IPC分类号： A61B17/00 ,  A61B17/30 ,  A61B17/34 ,  A61B18/14 ,  A61B19/00 ,  A61B18/18

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

公开(公告)号：US08038671B2

公开(公告)日：2011-10-18

申请号：US11464755

申请日：2006-08-15

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗卵圆孔卵泡（PFO）的方法和装置提供用导管装置向邻近PFO的组织施加能量，以基本上封闭PFO。 装置通常包括导管装置，其具有在其远端处或其近端处的至少一个能量传递构件，其被配置为向PFO组织施加能量以急剧，基本上关闭PFO。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。 导管装置的一些实施例还包括靠近远端的一个或多个组织定位构件，用于帮助使PFO组织在一起，例如PFO覆盖构件，真空施加构件等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US08021362B2

公开(公告)日：2011-09-20

申请号：US11613422

申请日：2006-12-20

申请人： Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto

发明人： Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of layered tissue defects having a majority of the surfaces of the defect layers in contact generally involve use of a catheter having at least one energy transmission member at its distal end. The distal end of the apparatus also typically has a force applying member which can apply a force to the tissue defect. Often this force is a lateral force or vacuum which helps the tissue to appose itself. An exemplary method of closing a patent foramen ovale (PFO) involves positioning a closure device between layers of the PFO. Energy is then applied to the layered tissue defect with the closure device so as to substantially close the tissue defect. The energy is often monopolar or bipolar radiofrequency energy. A force may also be applied by the closure device to the layered tissue defect so as to bring the layered tissue defect together.

摘要翻译： 用于治疗具有接触缺陷层的大部分表面的层状组织缺陷的方法和装置通常涉及在其远端使用具有至少一个能量传递构件的导管。 该装置的远端通常还具有可施加力到组织缺损的施力部件。 这种力通常是侧向力或真空，有助于组织自身。 闭合卵孔卵泡（PFO）的示例性方法涉及将闭合装置定位在PFO的层之间。 然后用闭合装置将能量施加到层状组织缺陷，以便基本上封闭组织缺损。 能量通常是单极或双极射频能量。 还可以通过闭合装置将力施加到层状组织缺陷，以使层状组织缺陷在一起。

公开(公告)号：US08052678B2

公开(公告)日：2011-11-08

申请号：US11622194

申请日：2007-01-11

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods, devices and systems for treating patent foramen ovale (PFO) involve advancing a catheter device to a position in a heart for treating a PFO, bringing tissues adjacent the PFO at least partially together, and applying energy to the tissues to substantially close the PFO acutely. Catheter devices generally include an elongate catheter body, at least one tissue apposition member at or near the distal end for bringing the tissues together, and at least one energy transmission member at or near the distal end for applying energy to the tissues. In some embodiments, the tissue apposition member(s) also act as the energy transmission member(s). Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like.

摘要翻译： 用于治疗卵孔卵泡（PFO）的方法，装置和系统涉及将导管装置推进到心脏中的位置以治疗PFO，使与PFO相邻的组织至少部分地在一起，并且向组织施加能量以基本上封闭PFO 急剧地 导管装置通常包括细长导管主体，位于或靠近远端的至少一个组织定位构件，用于将组织带到一起，以及在远端处或附近的至少一个能量传递构件，用于向组织施加能量。 在一些实施例中，组织安置构件也用作能量传递构件。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。

公开(公告)号：US08465485B2

公开(公告)日：2013-06-18

申请号：US13234908

申请日：2011-09-16

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods, devices and systems for treating patent foramen ovale (PFO) involve advancing a catheter device to a position in a heart for treating a PFO, bringing tissues adjacent the PFO at least partially together, and applying energy to the tissues to substantially close the PFO acutely. Catheter devices generally include an elongate catheter body, at least one tissue apposition member at or near the distal end for bringing the tissues together, and at least one energy transmission member at or near the distal end for applying energy to the tissues. In some embodiments, the tissue apposition member(s) also act as the energy transmission member(s). Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like.

摘要翻译： 用于治疗卵孔卵泡（PFO）的方法，装置和系统涉及将导管装置推进到心脏中的位置以治疗PFO，使与PFO相邻的组织至少部分地在一起，并且向组织施加能量以基本上封闭PFO 急剧地 导管装置通常包括细长导管主体，位于或靠近远端的至少一个组织定位构件，用于将组织带到一起，以及在远端处或附近的至少一个能量传递构件，用于向组织施加能量。 在一些实施例中，组织安置构件也用作能量传递构件。 施加的能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。

公开(公告)号：US07922716B2

公开(公告)日：2011-04-12

申请号：US11049791

申请日：2005-02-02

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosus, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.

摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。

公开(公告)号：US07367975B2

公开(公告)日：2008-05-06

申请号：US10952492

申请日：2004-09-27

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2018/00214 ,  A61B2018/00291 ,  A61B2018/00351

摘要： Methods for treating anatomic tissue defects such as patent foramen ovale (PFO) generally involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, exposing an expandable housing and energy transmission member out of the distal end of the catheter device, engaging the housing with tissues at the site of the anatomic defect, applying suction to the tissues via the housing to bring the tissues together; and applying energy to the tissues with the energy transmission member to substantially close the anatomic defect acutely. Apparatus generally include an elongate catheter body, a housing extending from a distal end of the catheter body for engaging tissues at the site of the anatomic defect, and an energy transmission member adjacent a distal end of the housing, the energy transmission member having at least one substantially planar surface.

摘要翻译： 用于治疗解剖组织缺陷如卵圆孔（PFO）的方法通常涉及将细长导管装置的远端定位在解剖缺损部位，将可扩张的壳体和能量传递构件暴露于导管装置的远端 将所述壳体与所述解剖缺陷部位的组织接合，通过所述壳体向所述组织施加吸力以将所述组织带在一起; 以及用能量传递构件向组织施加能量以急剧地基本上闭合解剖缺陷。 装置通常包括细长的导管主体，从导管主体的远端延伸的壳体，用于接合解剖缺陷部位的组织，以及邻近壳体的远端的能量传递构件，能量传递构件至少具有 一个基本平坦的表面。

公开(公告)号：US07293562B2

公开(公告)日：2007-11-13

申请号：US10873348

申请日：2004-06-21

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B19/00 ,  A61B18/18

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosis, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.

摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。

公开(公告)号：US08133221B2

公开(公告)日：2012-03-13

申请号：US11771528

申请日：2007-06-29

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2018/00214 ,  A61B2018/00291 ,  A61B2018/00351

摘要： Methods for treating anatomic tissue defects such as patent foramen ovale (PFO) generally involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, exposing an expandable housing and energy transmission member out of the distal end of the catheter device, engaging the housing with tissues at the site of the anatomic defect, applying suction to the tissues via the housing to bring the tissues together; and applying energy to the tissues with the energy transmission member to substantially close the anatomic defect acutely. Apparatus generally include an elongate catheter body, a housing extending from a distal end of the catheter body for engaging tissues at the site of the anatomic defect, and an energy transmission member adjacent a distal end of the housing, the energy transmission member having at least one substantially planar surface.

摘要翻译： 用于治疗解剖组织缺陷如卵圆孔（PFO）的方法通常涉及将细长导管装置的远端定位在解剖缺损部位，将可扩张的壳体和能量传递构件暴露于导管装置的远端 将所述壳体与所述解剖缺陷部位的组织接合，通过所述壳体向所述组织施加吸力以将所述组织带在一起; 以及用能量传递构件向组织施加能量以急剧地基本上闭合解剖缺陷。 装置通常包括细长的导管主体，从导管主体的远端延伸的壳体，用于接合解剖缺陷部位的组织，以及邻近壳体的远端的能量传递构件，能量传递构件至少具有 一个基本平坦的表面。

公开(公告)号：US20120010607A1

公开(公告)日：2012-01-12

申请号：US13234908

申请日：2011-09-16

申请人： William MALECKI ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William MALECKI ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B17/03 ,  A61B18/18

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods, devices and systems for treating patent foramen ovale (PFO) involve advancing a catheter device to a position in a heart for treating a PFO, bringing tissues adjacent the PFO at least partially together, and applying energy to the tissues to substantially close the PFO acutely. Catheter devices generally include an elongate catheter body, at least one tissue apposition member at or near the distal end for bringing the tissues together, and at least one energy transmission member at or near the distal end for applying energy to the tissues. In some embodiments, the tissue apposition member(s) also act as the energy transmission member(s). Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like.

摘要翻译： 用于治疗卵孔卵泡（PFO）的方法，装置和系统涉及将导管装置推进到心脏中的位置以治疗PFO，使与PFO相邻的组织至少部分地在一起，并且向组织施加能量以基本上封闭PFO 急剧地 导管装置通常包括细长导管主体，位于或靠近远端的至少一个组织定位构件，用于将组织带到一起，以及在远端处或附近的至少一个能量传递构件，用于向组织施加能量。 在一些实施例中，组织安置构件也用作能量传递构件。 施加的能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。