公开(公告)号：US20230384297A1

公开(公告)日：2023-11-30

申请号：US18173246

申请日：2023-02-23

申请人： William Marsh Rice University

发明人： Peter B. LILLEHOJ ,  Jiran LI

IPC分类号： G01N33/543 ,  G01N33/58 ,  B01L3/00

CPC分类号： G01N33/54326 ,  G01N33/58 ,  B01L3/502761 ,  B01L2400/043

摘要： A simple immunosensor for rapid and high sensitivity measurements of protein biomarkers, such as SARS-CoV-2 nucleocapsid protein, in serum. The assay is based on a unique sensing scheme utilizing dually labeled magnetic nanobeads for immunomagnetic enrichment and signal amplification. This immunosensor can be integrated onto a microfluidic chip, which offers the advantages of minimal sample and reagent consumption, simplified sample handling, and enhanced detection sensitivity.
An ultrafast magneto-immunosensor, which employs AC electrothermally driven flow (ACEF) for accelerated mass transport and enhanced immunocomplex formation, is developed for high sensitivity protein measurement in whole blood samples.