公开(公告)号：US20240361307A1

公开(公告)日：2024-10-31

申请号：US18606701

申请日：2024-03-15

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Omid Farokhzad ,  Morteza Mahmoudi ,  Claudia Corbo

IPC: G01N33/543 ,  C01G49/02 ,  G01N33/574 ,  G01N33/68 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20 ,  B82Y35/00

CPC classification number: G01N33/5432 ,  C01G49/02 ,  G01N33/54326 ,  G01N33/57488 ,  G01N33/6842 ,  G01N33/6848 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20 ,  B82Y35/00 ,  C01P2004/64 ,  G06F2218/20

Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

公开(公告)号：US20240353406A1

公开(公告)日：2024-10-24

申请号：US18693672

申请日：2022-09-21

Applicant: UNIVERSITA' DEGLI STUDI DI MESSINA ,  ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA

Inventor： Sabrina CONOCI ,  Salvatore GUGLIELMINO ,  Matteo CALVARESI ,  Alberto DANIELLI ,  Luca PRODI ,  Enza FAZIO ,  Annapaola PETROSINO ,  Matteo DI GIOSIA

IPC: G01N33/569 ,  G01N21/64 ,  G01N33/543

CPC classification number: G01N33/56911 ,  G01N21/6486 ,  G01N33/54326 ,  G01N2333/01 ,  G01N2333/21

Abstract: A method for detecting cellular or molecular analytes is provided. The method uses two types of engineered phages: a “capture” phage (bait phage) and a “signal” phage (reporter phage). Through this method it is possible to selectively bind a target analyte and thus recognize said target analyte.

公开(公告)号：US20240310368A1

公开(公告)日：2024-09-19

申请号：US18400491

申请日：2023-12-29

Applicant: Calibra Scientific, Inc.

Inventor： Pengyun LIU ,  Meihua WANG ,  Yikun LI ,  Weijia WU ,  Huafen LIU

IPC: G01N33/543

CPC classification number: G01N33/54326

Abstract: The present invention provides a detection kit for catecholamines and metabolites thereof in plasma/urine and a detection method and use thereof. By adding a stabilizer into plasma and adding an acid into urine, substances to be tested in plasma/urine samples are maintained stable. The substances to be tested in the samples are adsorbed and extracted by a magnetic medium composite material, and then the contents of the catecholamines and metabolites thereof are detected by high performance liquid chromatography tandem mass spectrometry. The method is simple, efficient and suitable for samples from different sources, and has the advantages of good universality, high stability and long-term storage of samples, a high automation degree of an operation process, short time consumed and high sensitivity. The substances to be tested in the plasma and the urine are simultaneously extracted and detected by the same kit and the same detection method, so as to realize standardized operation for detection of the catecholamines and metabolites thereof.

公开(公告)号：US20240294897A1

公开(公告)日：2024-09-05

申请号：US18657335

申请日：2024-05-07

Applicant: BIOMAGNETIC SOLUTIONS LLC

Inventor： Paul A. LIBERTI ,  Todor R. KHRISTOV ,  Dustin W. RITTER

IPC: C12N13/00 ,  A61M1/36 ,  B01D15/38 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/033 ,  B03C1/034 ,  B03C1/28 ,  G01N33/543

CPC classification number: C12N13/00 ,  A61M1/3618 ,  B01D15/3885 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/034 ,  B03C1/288 ,  G01N33/54326 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26

Abstract: An apparatus and methods are provided for the magnetic separation of target bioentities. The apparatus includes a fluid chamber and a magnetic clement for drawing target bioentities toward a collection surface of the fluid chamber. The apparatus may include a positioning assembly operable to variable change the position and orientation of the fluid chamber relative to the magnetic element.

公开(公告)号：US12077600B2

公开(公告)日：2024-09-03

申请号：US17069349

申请日：2020-10-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hartmut Duefel ,  Alfred Engel ,  Frank Kroner ,  Thomas Meier ,  Sandra Rutz ,  Michael Schraeml ,  Gloria Tabares ,  Ulrike Kurtkaya ,  Boris Pinchuk ,  Christina Zimmermann

IPC: G01N31/00 ,  C07K16/40 ,  G01N33/53 ,  G01N33/543

CPC classification number: C07K16/40 ,  G01N33/54326 ,  C07K2317/92

Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.

公开(公告)号：US20240288399A1

公开(公告)日：2024-08-29

申请号：US18476812

申请日：2023-09-28

Applicant: KOREA ELECTRONICS TECHNOLOGY INSTITUTE

Inventor： Seong Eun KIM ,  Se Eun JEONG ,  Seo Eun LEE

IPC: G01N27/327 ,  G01N27/36 ,  G01N33/543

CPC classification number: G01N27/3278 ,  G01N27/3277 ,  G01N27/36 ,  G01N33/54326 ,  G01N33/5438 ,  G01N2446/20 ,  G01N2446/86

Abstract: Disclosed are a metal nanoparticle-magnetic particle complex, comprising a core comprising a magnetic particle, the first shell comprising metal nanoparticles and formed on the surface of the core, and the second shell comprising a response factor and formed on the surface of the first shell, a method of preparing the complex, and a method of measuring the concentration of a biomarker in a sample using the complex.

公开(公告)号：US20240280592A1

公开(公告)日：2024-08-22

申请号：US18651906

申请日：2024-05-01

Applicant: TOPPAN Holdings Inc. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Yoichi MAKINO ,  Takumi HIRASE ,  Kohei YUYAMA

IPC: G01N33/68 ,  G01N33/543

CPC classification number: G01N33/6896 ,  G01N33/54326 ,  G01N2333/28 ,  G01N2333/4709 ,  G01N2458/10

Abstract: There are provided a method for detecting amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, the method including: a step of binding amyloid-β bound to the brain-neuronal-cell-derived exosome in blood to an amyloid-β-specific binding substance that specifically binds to amyloid-β, labeled with a nucleic acid fragment; and a step of detecting the amyloid-β-specific binding substance, and a method for evaluating an accumulation level of amyloid-β in a brain, the method including: a step of detecting amyloid-β bound to the brain-neuronal-cell-derived exosome in blood; and a step of evaluating an accumulation level of amyloid-β in a brain based on the detected amount of the amyloid-β.

公开(公告)号：US20240280566A1

公开(公告)日：2024-08-22

申请号：US18644619

申请日：2024-04-24

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Omid Farokhzad ,  Morteza Mahmoudi ,  Claudia Corbo

IPC: G01N33/543 ,  B82Y35/00 ,  C01G49/02 ,  G01N33/574 ,  G01N33/68 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20

CPC classification number: G01N33/5432 ,  C01G49/02 ,  G01N33/54326 ,  G01N33/57488 ,  G01N33/6842 ,  G01N33/6848 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20 ,  B82Y35/00 ,  C01P2004/64 ,  G06F2218/20

Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

公开(公告)号：US20240230633A1

公开(公告)日：2024-07-11

申请号：US18562090

申请日：2022-05-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Aaron STELLA ,  Subhasish PURKAYASTHA

IPC: G01N33/543 ,  G01N33/94

CPC classification number: G01N33/54326 ,  G01N33/54353 ,  G01N33/94

Abstract: Methods and kits for preparing liquid samples are presently claimed and described. The method may include treating a liquid sample with enzyme-conjugated magnetic beads are suspended in a buffer solution that comprises at least one internal standard, hydrolyzing the liquid sample to prepare a hydrolysate, and purifying the hydrolysate with magnetic based purification. Kits for preparing a liquid sample can include the, a liquid chromatography column, one or more solvents to be used as mobile phases, one or more calibrant solutions, and instructions for use.

公开(公告)号：US20240183852A1

公开(公告)日：2024-06-06

申请号：US18285490

申请日：2022-04-08

Applicant: Pictor Limited ,  The University of Melbourne

Inventor： Anna Kanci Condello ,  Glenn Francis Browning ,  James Yazah Adamu ,  Jimena Maria Tejerina ,  Kelly Anne Tivendale ,  Wasala Mudiyanselage Nadeeka Jumari Wawegama ,  Philip Francis Markham ,  Sandeep Kumar Vashist

IPC: G01N33/569 ,  C07K16/12 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/56933 ,  C07K16/1253 ,  G01N33/54326 ,  G01N33/581 ,  G01N33/6854 ,  G01N2469/20

Abstract: Mycoplasma bovis infection in cattle is a major production limiting disease of cows and calves. M. bovis can cause a range of conditions in cattle. including mastitis in dairy cows. arthritis in cows and calves. pneumonia in calves, and various other diseases including late-term abortion. The present invention provides methods for detecting multiple anti-M. bovis antibodies in a single multiplex immunoassay.