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    Glucose sensing molecules having selected fluorescent properties
    3.
    发明授权
    Glucose sensing molecules having selected fluorescent properties 有权
    具有选择的荧光性质的葡萄糖感测分子

    公开(公告)号：US06682938B1

    公开(公告)日：2004-01-27

    申请号：US09663567

    申请日：2000-09-15

    申请人： Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Christopher B. Darrow ,  Douglas R. Cary ,  Joe Anh Tran

    发明人： Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Christopher B. Darrow ,  Douglas R. Cary ,  Joe Anh Tran

    IPC分类号： G01N3300

    CPC分类号： C09B19/00 ,  A61B5/14532 ,  A61B5/1459 ,  C07F5/025 ,  C09B57/08 ,  C09B57/10 ,  G01N33/52 ,  G01N33/66

    摘要： An analyte sensing fluorescent molecule that employs intramolecular electron transfer is designed to exhibit selected fluorescent properties in the presence of analytes such as saccharides. The selected fluorescent properties include excitation wavelength, emission wavelength, fluorescence lifetime, quantum yield, photostability, solubility, and temperature or pH sensitivity. The compound comprises an aryl or a substituted phenyl boronic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. The fluorophore and switch component are selected such that the value of the free energy for electron transfer is less than about 3.0 kcal mol−1. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

    摘要翻译： 使用分子内电子转移的分析物感测荧光分子被设计为在分析物例如糖的存在下显示选择的荧光性质。 所选择的荧光特性包括激发波长，发射波长，荧光寿命，量子产率，光稳定性，溶解度和温度或pH敏感性。 化合物包括用作底物识别组分的芳基或取代的苯基硼酸，荧光开关组分和荧光团。 选择荧光团和开关组分使得电子转移的自由能的值小于约3.0kcal mol -1。 描述了在波长大于400nm被激发并且以大于450nm的波长发射的荧光化合物，这对于通过皮肤的光学透射是有利的。 荧光团通常选自过渡金属 - 配体络合物和噻嗪，恶嗪，恶唑酮或恶嗪 - 以及蒽化合物。 荧光化合物可以固定在可植入皮肤下面的葡萄糖可渗透的生物相容性聚合物基质中。

    Saccharide sensing molecules having enhanced fluorescent properties
    4.
    发明授权
    Saccharide sensing molecules having enhanced fluorescent properties 有权
    具有增强的荧光性质的糖感测分子

    公开(公告)号：US06673625B2

    公开(公告)日：2004-01-06

    申请号：US09823522

    申请日：2001-03-30

    申请人： Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Christopher B. Darrow ,  Douglas R. Cary ,  Joe Anh Tran

    发明人： Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Christopher B. Darrow ,  Douglas R. Cary ,  Joe Anh Tran

    IPC分类号： G01N3300

    CPC分类号： C09B57/08 ,  A61B5/14532 ,  A61B5/1459 ,  C07F5/025 ,  C09B19/00 ,  C09B57/10 ,  G01N33/52 ,  G01N33/66 ,  Y10T436/143333 ,  Y10T436/144444

    摘要： The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

    摘要翻译： 本发明提供具有多种性质的荧光化合物的配方，使其独特地适用于分析物如糖的传感器。 有利的荧光特性包括有利的激发波长，发射波长，荧光寿命和光稳定性。 其他有利的性质包括提高水溶性，以及温度和pH敏感性。 化合物包括用作底物识别组分的芳基或取代的苯基苯甲酸，荧光开关组分和荧光团。 描述了在波长大于400nm被激发并且以大于450nm的波长发射的荧光化合物，这对于通过皮肤的光学透射是有利的。 荧光团通常选自过渡金属 - 配体络合物和噻嗪，恶嗪，恶唑酮或恶嗪 - 以及蒽化合物。 荧光化合物可以固定在可植入皮肤下面的葡萄糖可渗透的生物相容性聚合物基质中。

    Implantable medical sensor system
    5.
    发明授权
    Implantable medical sensor system 失效
    植入式医疗传感器系统

    公开(公告)号：US06201980B1

    公开(公告)日：2001-03-13

    申请号：US09166236

    申请日：1998-10-05

    申请人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    发明人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    IPC分类号： A61B505

    CPC分类号： A61B5/0031 ,  A61B5/14532 ,  A61B2562/028

    摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

    摘要翻译： 描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。 当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。 随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。 本发明可用于糖尿病患者血糖水平的微创监测。

    Chemical sensor system
    6.
    发明授权
    Chemical sensor system 失效
    化学传感器系统

    公开(公告)号：US06480730B2

    公开(公告)日：2002-11-12

    申请号：US09742775

    申请日：2000-12-20

    申请人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    发明人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    IPC分类号： A61B505

    CPC分类号： A61B5/0031 ,  A61B5/14532 ,  A61B2562/028

    摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

    摘要翻译： 描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。 当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。 随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。 本发明可用于糖尿病患者血糖水平的微创监测。