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公开(公告)号：US06443942B1
公开(公告)日：2002-09-03
申请号：US09876569
申请日：2001-06-06
IPC分类号： A61L3300
摘要： The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.
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2.发明授权Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权基于植入式酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US07722913B2
公开(公告)日：2010-05-25
申请号：US11096818
申请日：2005-03-31
IPC分类号： A61L33/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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3.发明授权Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权基于植入式酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US06934572B2
公开(公告)日：2005-08-23
申请号：US10286174
申请日：2002-10-31
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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4.发明授权Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces 有权可植入的基于酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US06477395B2
公开(公告)日：2002-11-05
申请号：US09395434
申请日：1999-09-14
IPC分类号： A61B500
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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公开(公告)号：US6119028A
公开(公告)日：2000-09-12
申请号：US954166
申请日：1997-10-20
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
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