公开(公告)号：US20100016607A1

公开(公告)日：2010-01-21

申请号：US12518751

申请日：2007-12-11

Applicant: William R. Dolbier, JR. ,  Krishna Murthy Janmanchi

Inventor： William R. Dolbier, JR. ,  Krishna Murthy Janmanchi

IPC: C07D213/61 ,  C01F7/50 ,  C07D213/26 ,  C07C25/13

CPC classification number: B01J37/03 ,  B01J27/122 ,  C01G3/04 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/03 ,  C01P2004/82 ,  C07B39/00 ,  C07C17/12 ,  C07C17/208 ,  Y02P20/582 ,  C07C25/13 ,  C07C25/22

Abstract: The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O2 and HF.

Abstract translation: 本发明涉及用于合成芳族化合物氟化的高活性二元金属氟化物体系的方法。 氟化芳族化合物是用于化学合成药物和新型聚合物的有价值的合成物。 氟苯用于控制钢铁制造中的碳含量，是药物，农药和其他有机化合物的中间体。 氟苯通常通过苯胺和亚硝酸钠在氟化氢存在下的反应来制备。 本发明涉及一种合成高活性二元金属氟化物体系的方法，其由氟化铜（II）和氟化铝（III）组成，用于在气相中氟化芳族化合物，并使用O2原位再循环试剂 和HF。