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公开(公告)号：US20100196938A1
公开(公告)日：2010-08-05
申请号：US12756875
申请日：2010-04-08
IPC分类号： G01N33/566 , G01N27/26
CPC分类号： G01N33/5308 , G01N33/5091 , G01N2800/42 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81
摘要： Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
摘要翻译： 提供了用于诊断具有与这种咬合或刺痛一致的症状的患者中的有毒生物的咬伤或刺痛的方法和免疫测定。 使用拭子从怀疑咬伤或刺痛的区域收集毒液样品，然后与特异性结合样品中存在的毒液上的抗原位点的抗体接触。 然后检测绑定。 本发明通过示出棕色隐窝蜘蛛咬伤诊断的实例进行说明，将其与常常混淆的其他诊断区分开来。 这种非常敏感的测试可以检测到毒液抗原降至20皮克，甚至在样品运输后，在夏天存放长达三周的时间。
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2.发明授权公开(公告)号：US07927828B2
公开(公告)日：2011-04-19
申请号：US11550130
申请日：2006-10-17
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/5091 , G01N2800/42 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81
摘要： Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
摘要翻译： 提供了用于诊断具有与这种咬合或刺痛一致的症状的患者中的有毒生物的咬伤或刺痛的方法和免疫测定。 使用拭子从怀疑咬伤或刺痛的区域收集毒液样品，然后与特异性结合样品中存在的毒液上的抗原位点的抗体接触。 然后检测绑定。 本发明通过示出棕色隐窝蜘蛛咬伤诊断的实例进行说明，将其与常常混淆的其他诊断区分开来。 这种非常敏感的测试可以检测到毒液抗原降至20皮克，甚至在样品运输后，在夏天存放长达三周的时间。
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3.发明授权公开(公告)号：US08426154B2
公开(公告)日：2013-04-23
申请号：US12756875
申请日：2010-04-08
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/5308 , G01N33/5091 , G01N2800/42 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81
摘要： Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
摘要翻译： 提供了用于诊断具有与这种咬合或刺痛一致的症状的患者中的有毒生物的咬伤或刺痛的方法和免疫测定。 使用拭子从怀疑咬伤或刺痛的区域收集毒液样品，然后与特异性结合样品中存在的毒液上的抗原位点的抗体接触。 然后检测绑定。 本发明通过示出棕色隐窝蜘蛛咬伤诊断的实例进行说明，将其与常常混淆的其他诊断区分开来。 这种非常敏感的测试可以检测到毒液抗原降至20皮克，甚至在样品运输后，在夏天存放长达三周的时间。
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