-
公开(公告)号：US08513190B2
公开(公告)日：2013-08-20
申请号：US13297522
申请日：2011-11-16
IPC分类号： A61K38/02
CPC分类号： A61K38/05 , A61K31/00 , A61K31/155 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/675 , A61K31/69 , A61K31/702 , A61K38/005 , A61K38/28 , A61K38/55 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for modification and regulation of type II diabetes by administering to an animal a therapeutically effective amount of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to treat type II diabetes but not sufficient to suppress the immune system of the animal.
摘要翻译： 本发明提供了通过向动物施用治疗有效量的二肽基肽酶IV（DPIV）或其药学上可接受的盐的抑制剂或其药学上可接受的盐来改变和调节II型糖尿病的方法，其中抑制剂具有抑制DPIV的Ki为10 nM或更少; 并且以足以治疗II型糖尿病但不足以抑制动物免疫系统的量施用抑制剂。
-
公开(公告)号：US20120165252A1
公开(公告)日：2012-06-28
申请号：US13297522
申请日：2011-11-16
CPC分类号： A61K38/05 , A61K31/00 , A61K31/155 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/675 , A61K31/69 , A61K31/702 , A61K38/005 , A61K38/28 , A61K38/55 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoproteinemia (such as chylomicrons, VLDL and LDL), and to regulate body fat and more generally lipid stores, and, more generally, for the improvement of metabolism disorders, especially those associated with diabetes, obesity and/or atherosclerosis.
摘要翻译： 本发明提供用于改变和调节葡萄糖和脂质代谢的方法和组合物，通常降低胰岛素抵抗，高血糖症，高胰岛素血症，肥胖症，高脂血症，高脂蛋白血症（如乳糜微粒，VLDL和LDL），并调节身体脂肪和更一般 脂类储存，更一般地，用于改善代谢障碍，特别是与糖尿病，肥胖症和/或动脉粥样硬化相关的疾病。
-
公开(公告)号：US08318669B2
公开(公告)日：2012-11-27
申请号：US12942313
申请日：2010-11-09
IPC分类号： A61K38/02
CPC分类号： A61K38/05 , A61K31/00 , A61K31/155 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/675 , A61K31/69 , A61K31/702 , A61K38/005 , A61K38/28 , A61K38/55 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to inhibit DPIV proteolysis of GLP-1 but not sufficient to suppress the immune system of the animal.
摘要翻译： 本发明提供了通过施用治疗有效量的二肽基肽酶IV（DPIV）抑制剂或其药学上可接受的盐来修饰和调节胰高血糖素样肽1（GLP-1）代谢的方法，其中抑制剂具有抑制Ki DPIV为10nM以下; 并且以足以抑制GLP-1的DPIV蛋白水解的量的量施用抑制剂，但不足以抑制动物的免疫系统。
-
公开(公告)号：US20110275568A1
公开(公告)日：2011-11-10
申请号：US13102533
申请日：2011-05-06
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
CPC分类号： A61K38/26 , A61K49/0008 , C07K14/605
摘要： The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
摘要翻译： 本发明涉及胰高血糖素相关肽及其用于预防或治疗涉及大肠的疾病的用途。 特别是现在已经证明，GLP-2的GLP-2和肽激动剂可引起大肠组织的增殖。 因此，本发明提供了在有需要的受试者中增殖大肠的方法。 此外，本发明的方法可用于治疗或预防大肠炎症状况，包括炎性肠病。
-
公开(公告)号：US07960344B2
公开(公告)日：2011-06-14
申请号：US12581032
申请日：2009-10-16
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
CPC分类号： A61K38/26 , A61K49/0008 , C07K14/605
摘要： The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
摘要翻译： 本发明涉及胰高血糖素相关肽及其用于预防或治疗涉及大肠的疾病的用途。 特别是现在已经证明，GLP-2的GLP-2和肽激动剂可引起大肠组织的增殖。 因此，本发明提供了在有需要的受试者中增殖大肠的方法。 此外，本发明的方法可用于治疗或预防大肠炎症状况，包括炎性肠病。
-
公开(公告)号：US07888317B2
公开(公告)日：2011-02-15
申请号：US11325527
申请日：2006-01-05
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
IPC分类号： A61K38/26
CPC分类号： A61K38/26 , C07K14/605
摘要： Glucagon-like peptide 2, a product of glucagon gene expression, and analogs of glucagon-like peptide 2, have been identified as gastrointestinal tissue growth factors. Their effects on the growth of small bowel and pancreatic islets are described. Their formulation as a pharmaceutical, and their therapeutic use in treating disorders of the bowel, are described.
摘要翻译： 胰高血糖素样肽2，胰高血糖素基因表达的产物和胰高血糖素样肽2的类似物已被鉴定为胃肠组织生长因子。 描述了它们对小肠和胰岛生长的影响。 描述了它们作为药物的制剂及其在治疗肠道疾病中的治疗用途。
-
公开(公告)号：US20120328527A1
公开(公告)日：2012-12-27
申请号：US13599966
申请日：2012-08-30
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
CPC分类号： A61K38/26 , A61K49/0008 , C07K14/605
摘要： The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
摘要翻译： 本发明涉及胰高血糖素相关肽及其用于预防或治疗涉及大肠的疾病的用途。 特别是现在已经证明，GLP-2的GLP-2和肽激动剂可引起大肠组织的增殖。 因此，本发明提供了在有需要的受试者中增殖大肠的方法。 此外，本发明的方法可用于治疗或预防大肠炎症状况，包括炎性肠病。
-
公开(公告)号：US08278273B2
公开(公告)日：2012-10-02
申请号：US13102533
申请日：2011-05-06
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
CPC分类号： A61K38/26 , A61K49/0008 , C07K14/605
摘要： The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
摘要翻译： 本发明涉及胰高血糖素相关肽及其用于预防或治疗涉及大肠的疾病的用途。 特别是现在已经证明，GLP-2的GLP-2和肽激动剂可引起大肠组织的增殖。 因此，本发明提供了在有需要的受试者中增殖大肠的方法。 此外，本发明的方法可用于治疗或预防大肠炎症状况，包括炎性肠病。
-
公开(公告)号：US07862824B2
公开(公告)日：2011-01-04
申请号：US10829201
申请日：2004-04-22
CPC分类号： A61K45/06 , A61K38/26 , A61K2300/00
摘要： The effects of GLP-2 are enhanced using a GLP-1 activity inhibitor. For medical use to treat or inhibit the onset of medical conditions, disorder or diseases for which treatment with GLP-2 is indicated, the present invention provides a pharmaceutical combination comprising a GLP-2 activity enhancer, and a GLP-1 activity inhibitor. The combination is useful particularly to treat gastrointestinal conditions such as small bowel syndrome, mucositis and Crohn's disease, and to suppress appetite, for instance to treat obesity.
摘要翻译： 使用GLP-1活性抑制剂增强GLP-2的作用。 用于治疗或抑制用于GLP-2治疗的医学病症，病症或疾病的医学用途，本发明提供了包含GLP-2活性增强剂和GLP-1活性抑制剂的药物组合。 该组合对于治疗诸如小肠综合征，粘膜炎和克罗恩病的胃肠道疾病以及抑制食欲，例如治疗肥胖症是有用的。
-
公开(公告)号：US07176182B2
公开(公告)日：2007-02-13
申请号：US10419150
申请日：2003-04-21
申请人： Daniel J. Drucker
发明人： Daniel J. Drucker
CPC分类号： A61K38/26 , A61K49/0008 , C07K14/605
摘要： The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.027 秒)
