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公开(公告)号：US20230031369A1
公开(公告)日：2023-02-02
申请号：US17620949
申请日：2020-06-30
发明人： Gernot Riedel , Valeria Melis , Charles Robert Harrington , Jochen Klein , Grazyna Niewiadomska , Marta Steczkowska , Karima Schwab , Claude Michel Wischil
IPC分类号： A61K31/5415 , A61P25/28 , A61K45/06
摘要： The present invention relates generally to methods of treatment of Alzheimer's Disease or Mild Cognitive Impairment which are adapted to avoid negative interactions between combinations of therapeutics. In particular there are disclosed such methods of treatment in which the order of therapeutics is actively controlled to mitigate homeostatic downregulation prior to administration of active, for example disease modifying, therapeutic agents. In certain embodiments therapy with symptomatic treatments (such as modifiers of the activity of acetylcholine or glutamate neurotransmitters) may subsequently be combined with the disease modifying or other active treatment. The invention also applies the findings in relation to homeostatic downregulation to novel methods of clinical trial design.
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公开(公告)号：US20220330594A1
公开(公告)日：2022-10-20
申请号：US17620956
申请日：2020-06-29
发明人： Gernot Riedel , Charles Robert Harrington , Jochen Klein , Karima Schwab , Claude Michel Wischik
摘要： The present invention relates generally to nootropic compositions comprising Leuco-methylthioninium acid salts and their uses for cognitive enhancement in normal (non-demented) individuals.
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