公开(公告)号：US20240327457A1

公开(公告)日：2024-10-03

申请号：US18434662

申请日：2024-02-06

Applicant: Wisconsin Alumni Research Foundation

Inventor： Shaoqin Gong ,  Min Zhu ,  Xianghui Xu

IPC: C07K5/02 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/711 ,  C07K1/107

CPC classification number: C07K5/0215 ,  A61K9/5123 ,  A61K31/7105 ,  A61K31/711 ,  C07K1/1077

Abstract: The present technology provides disulfide-containing lipopeptides of Formula I. Such lipids may be incorporated into lipid nanoparticles for delivery of nucleic acids, nucleotides (e.g., NAD+ or NADH), polypeptides (including proteins), and complexes of proteins and nucleic acids, e.g., Cas9 RNP. The present technology also provides methods for delivering the nanoparticles to a cell and methods of treating a condition or disorder using the lipid nanoparticles.