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公开(公告)号：US4436735A
公开(公告)日：1984-03-13
申请号：US439653
申请日：1982-11-05
IPC分类号： A61K31/704 , A61P9/00 , C07J19/00 , A61K31/585
CPC分类号： C07J19/005
摘要： The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R.sub.1 and R.sub.2 are identical alkyl radicals containing up to 3 carbon atoms or together represent a cyclic ketal containing 2 to 6 carbon atoms, R.sub.3 represents two hydrogen atoms, the group ##STR2## or the radical ##STR3## wherein R.sub.1 and R.sub.2 have the above-given meaning, and R.sub.4 is a hydrogen atom or a lower acyl or alkyl radical.The present invention also provides processes for the preparation of these ketals, as well as pharmaceutical compositions containing them, which are useful for the treatment of cardiac insufficiency.
摘要翻译： 本发明提供了通式为：其中R 1和R 2是含有至多3个碳原子的相同烷基或一起代表含有2至6个碳原子的环状缩酮的3“ - 脱氢伐尼洛德三唑一硫酮的缩酮 原子，R 3表示两个氢原子，基团
或基团 ，其中R 1和R 2具有上述含义，并且R 4是氢原子或低级酰基或烷基。 本发明还提供了制备这些缩酮的方法以及含有它们的药物组合物，其可用于治疗心功能不全。 -
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公开(公告)号：US4461763A
公开(公告)日：1984-07-24
申请号：US439654
申请日：1982-11-05
IPC分类号： C07J19/00 , A61K31/704 , A61P9/00 , C07J41/00
CPC分类号： C07J41/0016
摘要： The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R.sub.1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R.sub.2 is a hydrogen atom or a lower acyl or alkyl radical and R.sub.3 represents two hydrogen atoms, the group ##STR2## or the oximino group .dbd.NOR.sub.1, wherein R.sub.1 has the above-given meaning.The present invention also provides a process for the preparation of these oximes, as well as pharmaceutical compostions containing them which are useful for the treatment of cardiac insufficiency.
摘要翻译： 本发明提供具有以下通式的3' - 脱氢伐尼德定三叠氮酮肟：其中R 1是氢原子或含有至多3个碳原子的烷基，R 2是氢原子或低级酰基 或烷基，R 3表示两个氢原子，基团肟基或肟基= NOR1，其中R 1具有上述含义。 本发明还提供了制备这些肟的方法，以及含有它们的药物组合物，其可用于治疗心功能不全。
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3.发明授权2H-1-benzopyran-2-one derivatives, processes for the preparation thereof and pharmaceutical compositions containing them 失效2H-1-苯并吡喃-2-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4670439A
公开(公告)日：1987-06-02
申请号：US755496
申请日：1985-07-16
IPC分类号： A61K31/495 , A61P37/08 , C07D311/16 , C07D311/18 , C07D311/54 , C07D405/12
CPC分类号： C07D311/18 , C07D311/16 , C07D311/54
摘要： The present invention provides 2H-1-benzopyran-2-one derivatives of the general formula: ##STR1## wherein either R.sub.1 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.2 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl; or R.sub.1 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl, and R.sub.2 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.3 is a phenyl or benzyl radical which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these 2H-1-benzopyran-2-one derivatives and pharmaceutical compositions containing them.
摘要翻译： 本发明提供通式如下的1H-1-苯并吡喃-2-酮衍生物：其中R 1是任选被苯基取代的低级烷基，其可以被低级烷基，低级烷氧基， 羟基或卤素，R2是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单取代或二取代; 或R 1是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单或二取代，并且R 2是低级烷基， 被苯基取代，其可以被低级烷基，低级烷氧基，羟基或卤素取代，R3是可被低级烷基，低级烷氧基，羟基或卤素取代的苯基或苄基; 及其药理学上可接受的盐。 本发明还提供制备这些2H-1-苯并吡喃-2-酮衍生物的方法和含有它们的药物组合物。
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