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    2H-1-benzopyran-2-one derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
    1.
    发明授权
    2H-1-benzopyran-2-one derivatives, processes for the preparation thereof and pharmaceutical compositions containing them 失效
    2H-1-苯并吡喃-2-酮衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US4670439A

    公开(公告)日：1987-06-02

    申请号：US755496

    申请日：1985-07-16

    申请人： Ernst-Christian Witte ,  Peter Neubert ,  Androniki Roesch

    发明人： Ernst-Christian Witte ,  Peter Neubert ,  Androniki Roesch

    IPC分类号： A61K31/495 ,  A61P37/08 ,  C07D311/16 ,  C07D311/18 ,  C07D311/54 ,  C07D405/12

    CPC分类号： C07D311/18 ,  C07D311/16 ,  C07D311/54

    摘要： The present invention provides 2H-1-benzopyran-2-one derivatives of the general formula: ##STR1## wherein either R.sub.1 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.2 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl; or R.sub.1 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl, and R.sub.2 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.3 is a phenyl or benzyl radical which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these 2H-1-benzopyran-2-one derivatives and pharmaceutical compositions containing them.

    摘要翻译： 本发明提供通式如下的1H-1-苯并吡喃-2-酮衍生物：其中R 1是任选被苯基取代的低级烷基，其可以被低级烷基，低级烷氧基， 羟基或卤素，R2是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单取代或二取代; 或R 1是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单或二取代，并且R 2是低级烷基， 被苯基取代，其可以被低级烷基，低级烷氧基，羟基或卤素取代，R3是可被低级烷基，低级烷氧基，羟基或卤素取代的苯基或苄基; 及其药理学上可接受的盐。 本发明还提供制备这些2H-1-苯并吡喃-2-酮衍生物的方法和含有它们的药物组合物。

    Anti-allergy bicyclic phenol ethers
    6.
    发明授权
    Anti-allergy bicyclic phenol ethers 失效
    抗过敏双酚酚醚

    公开(公告)号：US4486442A

    公开(公告)日：1984-12-04

    申请号：US469856

    申请日：1983-02-25

    申请人： Walter-Gunar Friebe ,  Wolfgang Kampe ,  Androniki Roesch nee Apostolides ,  Wolfgang Schaumann

    发明人： Walter-Gunar Friebe ,  Wolfgang Kampe ,  Androniki Roesch nee Apostolides ,  Wolfgang Schaumann

    IPC分类号： A61K31/443 ,  A61K31/445 ,  A61P37/08 ,  C07D307/83 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

    CPC分类号： C07D401/12 ,  C07D307/83 ,  C07D405/12

    摘要： The present invention provides bicyclic phenol ethers of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom or an acyl radical,X is an oxygen or sulphur atom or an --NH-- group;Y is a --CO--CHR.sub.3 -- group or a ##STR2## group; R.sub.3 is a hydrogen atom, a lower alkyl radical which can be optionally substituted by an aryl radical, or a cycloalkyl radical containing 3 to 7 carbon atoms; andR.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms, lower alkyl radicals, lower alkyl radicals, alkenyl radicals containing 2 to 16 carbon atoms, which can be optionally substituted by an aryl radical, or an aryl radical; orR.sub.4 and R.sub.5, together with the carbon atom to which they are attached, form a cycloalkyl ring containing 3 to 7 carbon atoms; and thesalts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.

    摘要翻译： 本发明提供以下通式的双环酚醚：其中R 1为氢原子或低级烷基，R 2为氢原子或酰基，X为氧或硫原子或 - NH-基团; Y是-CO-CHR3-基团或基团; R3是氢原子，可任意被芳基取代的低级烷基或含有3至7个碳原子的环烷基; 和可以相同或不同的R 4和R 5是氢原子，低级烷基，低级烷基，含有2至16个碳原子的烯基，其可任选被芳基或芳基取代; 或R 4和R 5与它们所连接的碳原子一起形成含有3至7个碳原子的环烷基环; 其盐与药理学上可接受的酸。 本发明还提供了制备这些化合物的方法，以及含有它们的药物组合物。