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1.发明授权公开(公告)号：US07632828B2
公开(公告)日：2009-12-15
申请号：US11150522
申请日：2005-06-10
IPC分类号： C07D477/12 , A61K31/407 , A61P31/04 , A61K31/5377 , A61K31/426 , A61K31/4439 , A61K31/4995 , A61K31/496 , A61K31/4178
CPC分类号： C07D477/14 , A61K31/397 , A61K45/06 , Y02P20/55 , A61K2300/00
摘要： The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of the Formulae The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ÿ-methyl carbapenems which are useful as antibacterial agents.
摘要翻译： 本发明提供了用于治疗细菌感染的β-甲基碳青霉烯化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法，其中所述化合物通常为式。本发明包括给予有效量的 碳青霉烯化合物或其盐和/或前药给需要这种治疗的宿主。 本发明也在合成有机化学领域，并且具体提供了可用作抗菌剂的改进的合成甲基碳青霉烯的方法。
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2.发明申请公开(公告)号：US20100075945A1
公开(公告)日：2010-03-25
申请号：US12613795
申请日：2009-11-06
IPC分类号： A61K31/407 , C07D487/04 , A61P31/00
CPC分类号： C07D477/14 , A61K31/397 , A61K45/06 , Y02P20/55 , A61K2300/00
摘要： The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
摘要翻译： 本发明提供了用于治疗细菌感染的碳青霉烯类化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。 本发明也在合成有机化学领域中，并且具体提供了可用作抗菌剂的改进的碳青霉烯类甲基化合物的合成方法。
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3.发明授权Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors 失效从非循环的非手性前体制备3'-取代-2'，3'-二脱氧核苷和2'-脱氧核苷
公开(公告)号：US5432273A
公开(公告)日：1995-07-11
申请号：US960762
申请日：1992-10-14
申请人： Dennis C. Liotta , Michael W. Hager
发明人： Dennis C. Liotta , Michael W. Hager
摘要： A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-fluoro-3'-deoxythymidine, and 3'-fluoro-3'-deoxyuridine.
摘要翻译： 提供了制备3'-取代-2'，3'-双脱氧核苷的方法，其利用便宜的非碳水化合物，非环状的非手性起始原料，并且进行高对映体和立体化学控制。 该方法可用于制备药学上重要的化合物3'-叠氮基-3'-脱氧胸苷，3'-叠氮基-2'，3'-二脱氧尿苷，3'-氟-3'-脱氧胸苷和3'-氟 - 3'-脱氧尿苷。
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4.发明授权Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors 失效从非循环的非手性前体制备3'-取代-2'，3'-二脱氧核苷和2'-脱氧核苷
公开(公告)号：US5414078A
公开(公告)日：1995-05-09
申请号：US681109
申请日：1991-04-05
申请人： Dennis C. Liotta , Michael W. Hager
发明人： Dennis C. Liotta , Michael W. Hager
摘要： A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine and 3'-fluoro-3'-deoxythymidine.
摘要翻译： 提供了制备3'-取代-2'，3'-双脱氧核苷和2'-脱氧核苷的方法，其利用便宜的非碳水化合物，非环状的非手性起始原料，并且进行高对映体和立体化学控制。 该方法可用于制备药学上重要的化合物3'-叠氮基-3'-脱氧胸苷，3'-叠氮基-2'，3'-二脱氧尿苷和3'-氟-3'-脱氧胸苷。
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