公开(公告)号：US20240326041A1

公开(公告)日：2024-10-03

申请号：US18621550

申请日：2024-03-29

Applicant: Worcester Polytechnic Institute

Inventor： Hamilton A. White ,  Dirk R. Albrecht

IPC: B01L3/00

CPC classification number: B01L3/5027

Abstract: A microfluidic device for evaluation of test subjects for induced neural injury performs testing of multiple test subjects based on uniform and repeatable test stimuli for evaluating neural response for research including traumatic brain injury. A microfluidic device contains multiple test subjects and delivers a consistent, measured test stimuli simulating TBI to each of the test subjects simultaneously. The result is a system to assess neural function, behavior, and neural structure of small animals responsive to sonication-induced traumatic brain injury, to investigate risk and potential recovery. The microfluidic device disposes test subjects at a uniform distance from an injury inducing surface that emits sonication energy to simulate TBI. The uniform distance ensures that each test subject receives the same, controlled injury stimuli, and the test subjects may be evaluated with an attached microscope or video input, or may be extracted from the microfluidic device for further evaluation.