公开(公告)号：US20050278929A1

公开(公告)日：2005-12-22

申请号：US10869135

申请日：2004-06-16

申请人： Wun-Hsing Lee

发明人： Wun-Hsing Lee

IPC分类号： A61F2/90 ,  A61L31/10 ,  A61L31/16 ,  B23H9/00 ,  B23P25/00 ,  C25F3/16

CPC分类号： B23H9/00 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/624 ,  C25F3/16 ,  Y10T29/49885 ,  Y10T29/49996

摘要： The present invention provides a method for fabricating an implant stent with therapeutic effects. The method of the present invention includes designing and delineating a pattern of the implant stent, drilling a thin metal sheet to form positioning holes, cutting a desired pattern on the thin metal sheet according to the designed pattern, drilling a hole on a line rib of the stent to form a braided structure by a micro discharge processor according to the desired pattern. Then, the stent is cleaned and polished by the electropolish to trim the edge and the rough surface of the stent. Then, the biodegradable material, PLLA, PGA, fibrinogen, the polyurethane-polyethylene oxide mixed with the heparin or the combination thereof, is used for forming the mixed material with the high molecular weight, and is solved in a solvent, wherein another grinded therapeutic drug with the micro or the nano size is added. The drug can be As2O5, an anti-caner drug, or an anti-inflammation drug. The solution with the bioadsordable material having a therapeutic drug is atomized and sprayed on the outer and inner surfaces of the stent. Since a row of holes are arranged on the line rib of the stent, each hole is immersed into the solution due to the capillary phenomenon. When the solution is completely evaporated, the biodegradable and absordable material and the drug are coagulated to form a solid and to strongly coat on the surface of the stent. When the stent is implanted into a human body, the solid layer is slowly degraded and released on the injured site, so that the vessel is prevented from restenosis, and the therapeutic effect is achieved. The stent can be fabricated by the precision machine technology in Taiwan, so that the implant stent with low cost and therapeutic effects is obtained.

摘要翻译： 本发明提供一种用于制造具有治疗效果的植入物支架的方法。 本发明的方法包括设计和描绘植入支架的图案，钻出薄金属片以形成定位孔，根据设计图案在薄金属片上切割期望的图案，在线肋上钻孔 所述支架根据所需图案由微型放电处理器形成编织结构。 然后，通过电抛光清洁和抛光支架，以修剪支架的边缘和粗糙表面。 然后，将生物降解材料，PLLA，PGA，纤维蛋白原，与肝素混合的聚氨酯 - 聚环氧乙烷或其组合用于形成高分子量的混合材料，并溶解在溶剂中，其中另一研磨的治疗 加入微量或纳米尺寸的药物。 药物可以是抗癌药物或抗炎药物。 具有治疗药物的生物可提供材料的溶液被雾化并喷射在支架的外表面和内表面上。 由于在支架的线肋上布置有一排孔，所以由于毛细管现象，每个孔浸入溶液中。 当溶液完全蒸发时，可生物降解和可吸收的材料和药物被凝结以形成固体并且强力地涂覆在支架的表面上。 当支架植入人体时，固体层在受伤部位缓慢降解释放，防止血管再狭窄，达到治疗效果。 支架可以通过台湾的精密机械技术制造，从而获得低成本和治疗效果的植入支架。