公开(公告)号：US10677787B2

公开(公告)日：2020-06-09

申请号：US15847203

申请日：2017-12-19

申请人： X-Body, Inc.

发明人： Yan Chen ,  Tod M. Woolf ,  Richard W. Wagner

IPC分类号： C40B50/06 ,  G01N33/543 ,  G01N33/68 ,  C07K16/00 ,  C07K16/28 ,  C40B30/04

摘要： Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.

公开(公告)号：US11629434B2

公开(公告)日：2023-04-18

申请号：US16862851

申请日：2020-04-30

申请人： X-Body, Inc.

发明人： Yan Chen ,  Tod M. Woolf ,  Richard W. Wagner

IPC分类号： C40B30/04 ,  G01N33/68 ,  C07K16/00 ,  C07K16/28 ,  G01N33/543 ,  C40B50/06

摘要： Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.