公开(公告)号：US20250034247A1

公开(公告)日：2025-01-30

申请号：US18885447

申请日：2024-09-13

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Matthew Bernett ,  Rumana Rashid ,  John Desjarlais

IPC: C07K16/28 ,  C07K1/18 ,  C07K16/00 ,  C07K16/46

Abstract: The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.

公开(公告)号：US11981717B2

公开(公告)日：2024-05-14

申请号：US17578265

申请日：2022-01-18

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John Desjarlais ,  Rajat Varma ,  Rumana Rashid

IPC: C07K14/55 ,  C07K14/735 ,  C12N15/85 ,  A61K38/00

CPC classification number: C07K14/55 ,  C07K14/70535 ,  C12N15/85 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.

公开(公告)号：US11634506B2

公开(公告)日：2023-04-25

申请号：US16918922

申请日：2020-07-01

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Matthew Bernett ,  Rumana Rashid ,  John Desjarlais

IPC: C07K16/46 ,  C07K16/28

Abstract: The invention provides novel heterodimeric proteins including heterodimeric antibodies.

公开(公告)号：US11618776B2

公开(公告)日：2023-04-04

申请号：US16724118

申请日：2019-12-20

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Gregory Moore ,  Juan Diaz ,  Alex Nisthal ,  Ke Liu ,  Rumana Rashid ,  Eric Chang

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00

Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an NKG2D antigen binding domain Fc fusion proteins.

公开(公告)号：US20220195048A1

公开(公告)日：2022-06-23

申请号：US17692755

申请日：2022-03-11

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Rumana Rashid ,  John Desjarlais ,  Rajat Varma ,  Christine Bonzon

IPC: C07K16/28 ,  C12N15/63 ,  A61P35/00 ,  C07K14/54 ,  C07K14/715

Abstract: The present invention is directed to novel IL15/IL15Rα heterodimeric Fc fusion proteins.

公开(公告)号：US10858417B2

公开(公告)日：2020-12-08

申请号：US14216705

申请日：2014-03-17

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Matthew Bernett ,  Rumana Rashid ,  John Desjarlais

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/22

Abstract: In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.

公开(公告)号：US10738132B2

公开(公告)日：2020-08-11

申请号：US14155334

申请日：2014-01-14

Applicant: Xencor, Inc.

Inventor： John R. Desjarlais ,  Gregory L. Moore ,  Rumana Rashid ,  Matthew J. Bernett

IPC: C07K16/00 ,  C07K16/46 ,  C07K16/28

Abstract: The invention provides novel heterodimeric proteins including heterodimeric antibodies.

公开(公告)号：US20200216509A1

公开(公告)日：2020-07-09

申请号：US16592656

申请日：2019-10-03

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Ke Liu ,  Nargess Hassanzadeh-Kiabi ,  Rumana Rashid

IPC: C07K14/54 ,  C07K1/18

Abstract: The present invention provides novel IL-12 Fc fusion proteins, methods of making and using the same. The IL-12. Fc fusion proteins are useful for treatment of cancer and can be used in combination with checkpoint blockade.

公开(公告)号：US20200040083A1

公开(公告)日：2020-02-06

申请号：US16660028

申请日：2019-10-22

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Rumana Rashid ,  John Desjarlais ,  Rajat Varma ,  Christine Bonzon

IPC: C07K16/28 ,  C12N15/63 ,  A61P35/00 ,  C07K14/54 ,  C07K14/715

Abstract: The present invention is directed to novel IL15/IL15Rα heterodimeric Fc fusion proteins.

公开(公告)号：US20190270810A1

公开(公告)日：2019-09-05

申请号：US16162172

申请日：2018-10-16

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Matthew Bernett ,  Rumana Rashid ,  John Desjarlais

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/46

Abstract: The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.