公开(公告)号：US20210047262A1

公开(公告)日：2021-02-18

申请号：US16583263

申请日：2019-09-26

申请人： XI'AN JIAOTONG UNIVERSITY

发明人： JIAN-KANG LIU ,  XU-YUN LIU ,  YA-CHONG HU ,  LIN ZHAO ,  YONG-YAO WANG ,  CAI-YUE ZHU ,  ZHEN WANG ,  JING LOU ,  QING-QING MA ,  YU-XIA ZHANG ,  QING-LIN JIANG ,  XIAO-HONG XU ,  TING-HUA ZHANG ,  JIAN-GANG LONG

IPC分类号： C07C69/30 ,  A61P9/10

摘要： The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.