公开(公告)号：US20220256879A1

公开(公告)日：2022-08-18

申请号：US17627896

申请日：2020-07-20

申请人： Arthur Branwell & Co Limited

发明人： William Henry DENYER ,  Cheryl LOCKETT ,  Kenneth LAIDLAW

IPC分类号： A23D9/05 ,  C07C69/30

摘要： A cryo-crystallised particulate fat and method for producing such a fat, having reduced D[4,3], D[3,2] and D(50) than particulate fats known in the art, as measured by laser diffraction. Particles are formed by alterations to product throughput, air pressure and flow rate. The particles offer increased functionality in various food applications.

公开(公告)号：US10314878B2

公开(公告)日：2019-06-11

申请号：US15324873

申请日：2015-07-17

申请人： ZHEJIANG KANGLAITE GROUP CO., LTD.

发明人： Dapeng Li

IPC分类号： A61K8/92 ,  A61K36/8994 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/21 ,  A61K9/00 ,  A61K31/23 ,  A61K31/231 ,  A61K47/10 ,  A61K47/24 ,  C07C69/30 ,  C07C69/58 ,  C07C69/587 ,  C11B1/10 ,  C11B3/00 ,  A61K47/14 ,  A61K47/44

摘要： The present invention relates to Coix seed oil extracted from Semen Coicis, pharmaceutical preparations thereof, and the use thereof in the treatment of tumors. Specifically, the Coix seed oil contains 11 triglyceride ingredients in the following mass percentages: trilinolein 4.87-6.99%, 1-olein-2,3-dilinolein 13.00-18.69%, 1-palmitin-2,3-dilinolein 5.25-7.54%, 1,3-diolein-2-linolein 13.23-19.02%, 1-palmitin-2-linolein-3-olein 10.26-14.75%, 1,3-dipalmitin-2-linolein 2.28-3.28%, triolein 14.44-20.76% and 1-palmitin-2,3-diolein 8.06-11.58%, 1-olein-2-linolein-3-stearin 1.37-1.97%, 1,3-dipalmitin-2-olein 1.52-2.19% and 1,2-diolein-3-stearin 1.29-1.86%.

公开(公告)号：US10112918B2

公开(公告)日：2018-10-30

申请号：US14785075

申请日：2014-04-21

申请人： Kunming Institute of Botany, The Chinese Academy of Sciences ,  The Key Laboratory of Chemistry for Natural Product of Guizhou Province & Chinese Academy of Science ,  Shanghai Institutes for Biological Sciences, CAS ,  Institute of Zoology, Chinese Academy of Sciences

发明人： Xiaojiang Hao ,  Chen Yan ,  Haiyang Liu ,  Lin Li ,  Xiaoli He ,  Quan Chen

IPC分类号： C07C69/16 ,  C07C69/18 ,  C07C69/26 ,  C07C69/30 ,  C07C69/63 ,  C07C69/78 ,  C07C49/743 ,  C07C62/38 ,  C07C205/57 ,  C07D295/116 ,  C07D295/185 ,  C07D333/40 ,  C07D311/78 ,  A61K31/366 ,  C07D311/94 ,  C07D407/12 ,  C07D221/28 ,  C07D327/10 ,  C07D409/12 ,  C07D493/08 ,  C07D493/10 ,  C07D495/04 ,  C07D498/08 ,  C07C309/66 ,  C07C49/753

摘要： The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.

公开(公告)号：US20170209517A1

公开(公告)日：2017-07-27

申请号：US15324873

申请日：2015-07-17

申请人： ZHEJIANG KANGLAITE GROUP CO., LTD.

发明人： DAPENG LI

IPC分类号： A61K36/8994 ,  C11B3/00 ,  C07C69/587 ,  C07C69/58 ,  A61K9/48 ,  A61K31/231 ,  A61K31/23 ,  A61K47/24 ,  A61K47/10 ,  A61K9/00 ,  C11B1/10 ,  C07C69/30

CPC分类号： A61K36/8994 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4833 ,  A61K9/4858 ,  A61K31/21 ,  A61K31/23 ,  A61K31/231 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44 ,  A61K2236/35 ,  A61K2236/37 ,  C07C69/30 ,  C07C69/58 ,  C07C69/587 ,  C11B1/104 ,  C11B3/001 ,  C11B3/006 ,  C11B3/008

摘要： The present invention relates to Coix seed oil extracted from Semen Coicis, pharmaceutical preparations thereof, and the use thereof in the treatment of tumors. Specifically, the Coix seed oil contains 11 triglyceride ingredients in the following mass percentages: trilinolein 4.87-6.99%, 1-olein-2,3-dilinolein 13.00-18.69%, 1-palmitin-2,3-dilinolein 5.25-7.54%, 1,3-diolein-2-linolein 13.23-19.02%, 1-palmitin-2-linolein-3-olein 10.26-14.75%, 1,3-dipalmitin-2-linolein 2.28-3.28%, triolein 14.44-20.76% and 1-palmitin-2,3-diolein 8.06-11.58%, 1-olein-2-linolein-3-stearin 1.37-1.97%, 1,3-dipalmitin-2-olein 1.52-2.19% and 1,2-diolein-3-stearin 1.29-1.86%.

公开(公告)号：US20160369308A1

公开(公告)日：2016-12-22

申请号：US14898933

申请日：2014-06-20

申请人： AVRIL ,  UNIVERSITE PARIS-SUID

发明人： FRANCE THEVENIEAU ,  MARIE-JOËLLE VIROLLE ,  THIERRY DULERMO ,  MAXIME VERGNE

IPC分类号： C12P7/64 ,  C12N1/32 ,  C10L1/02 ,  C07C69/533 ,  C07C69/30 ,  C12N1/20 ,  C12N1/38

CPC分类号： C12P7/6463 ,  C07C69/30 ,  C07C69/533 ,  C10L1/02 ,  C10L2200/0476 ,  C10L2290/26 ,  C12N1/20 ,  C12N1/32 ,  C12N1/38 ,  C12P7/6445

摘要： The invention relates to the use of glycerol, or a C3-C5 sugar, as the main carbon source during the culturing of actinomyces bacteria for the production of lipids by said bacteria.

摘要翻译： 本发明涉及在用于由所述细菌产生脂质的放线菌细菌培养期间使用甘油或C3-C5糖作为主要碳源。

公开(公告)号：US08846107B2

公开(公告)日：2014-09-30

申请号：US13331304

申请日：2011-12-20

申请人： Junzhong Li ,  David D. McSherry ,  Richard Staub

发明人： Junzhong Li ,  David D. McSherry ,  Richard Staub

IPC分类号： A61L2/18 ,  C07C409/24 ,  C07C69/30 ,  C07C69/33 ,  A01N37/12 ,  A01N37/16

CPC分类号： A01N37/16 ,  A01N37/12 ,  C07C409/24 ,  A01N31/02 ,  A01N2300/00 ,  A01N59/00

摘要： The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting materials. Methods for using the percarboxylic acid compositions are also disclosed.

摘要翻译： 本公开涉及在非平衡反应中原位形成的过羧酸组合物。 过氧羧酸组合物使用酯基原料形成。 还公开了使用过羧酸组合物的方法。

公开(公告)号：US08476319B2

公开(公告)日：2013-07-02

申请号：US11908185

申请日：2006-03-10

申请人： Matthew T. Scholz ,  Danli Wang ,  Jeffrey F. Andrews

发明人： Matthew T. Scholz ,  Danli Wang ,  Jeffrey F. Andrews

IPC分类号： A61K31/23 ,  C07C69/533 ,  C07C69/58 ,  C07C69/28 ,  C07C69/30 ,  A61K31/225

CPC分类号： A61K31/20 ,  A61K31/045 ,  A61K31/075 ,  A61K31/19 ,  A61K31/215 ,  A61K31/23 ,  A61K31/231 ,  A61K2300/00

摘要： Methods of treating and/or preventing otitis media in a subject are provided. Methods of treating and/or preventing otitis externa are also provided.

摘要翻译： 提供了治疗和/或预防受试者中耳炎的方法。 还提供治疗和/或预防外耳炎的方法。

公开(公告)号：US08188019B2

公开(公告)日：2012-05-29

申请号：US12480032

申请日：2009-06-08

申请人： Saleh A. Elomari ,  Stephen Joseph Miller ,  Zhen Zhou

发明人： Saleh A. Elomari ,  Stephen Joseph Miller ,  Zhen Zhou

IPC分类号： C10M105/38 ,  C07C69/30

CPC分类号： B01J35/0006 ,  B01J23/26 ,  B01J29/87 ,  B01J35/1019 ,  B01J37/031 ,  B01J37/18 ,  C01B39/082 ,  C07C29/106 ,  C07C29/147 ,  C07C67/08 ,  C07C69/30 ,  C10G2/33 ,  C10G2/334 ,  C10G2300/1011 ,  C10G2300/302 ,  C10G2300/304 ,  C10G2400/10 ,  C10L1/06 ,  C10M129/74 ,  C10M2207/283 ,  C10N2270/00 ,  Y02P30/20 ,  C07C33/22 ,  C07C33/025

摘要： The present invention is generally directed to triester-based lubricant compositions. The present invention is also directed to methods of making these and other similar lubricant compositions. In some embodiments, the methods for making such triester-based lubricants utilize a biomass precursor comprising mono-unsaturated fatty acids, wherein such mono-unsaturated fatty acids are reduced to mono-unsaturated fatty alcohols en route to the synthesis of triester species for use as/in the triester-based lubricant compositions. Subsequent steps in such synthesis may employ carboxylic acids and/or acyl halides/anhydrides derived from biomass and/or Fischer-Tropsch synthesis.

公开(公告)号：US20060099693A1

公开(公告)日：2006-05-11

申请号：US10513576

申请日：2003-05-05

申请人： Joseph Kobzeff ,  Craig Weaver

发明人： Joseph Kobzeff ,  Craig Weaver

IPC分类号： C12P7/64 ,  A61K31/225 ,  C07C69/30

CPC分类号： A23D9/00 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/202 ,  C11B1/025 ,  C11B3/001 ,  C11B5/0021 ,  C12N1/06 ,  C12N1/066 ,  C12P7/6472 ,  A23V2250/1882

摘要： A high-quality lipid composition is disclosed having low oxidative deterioration such as measured by low anisidine values. Also disclosed are methods of preparing the same from a lipid-containing material that include enzymatic degradation of protein and/or carbohydrate components of the material. Lipid-containing materials include biomass, such as microorganisms. The invention further includes products containing the lipid compositions, such as dietary supplements, food products, pharmaceutical formulations, humanized animal milk, and infant formula.

摘要翻译： 公开了具有低氧化劣化的高质量脂质组合物，例如通过低茴香胺值测量的。 还公开了从包含材料的蛋白质和/或碳水化合物成分的酶降解的含脂质材料制备该方法。 含脂质的材料包括生物质，如微生物。 本发明还包括含有脂质组合物的产品，例如膳食补充剂，食品，药物制剂，人源化动物奶和婴儿配方食品。

公开(公告)号：US20050124051A1

公开(公告)日：2005-06-09

申请号：US11014658

申请日：2004-12-16

申请人： Antonia Jekkel ,  Gabor Ambrus ,  Eva Ilkoy ,  Ildiko Horvath ,  Attila Konya ,  Istvan Szabo ,  Zsuzsanna Nagy ,  Gyula Horvath ,  Julia Mozes ,  Istvan Barta ,  Gyorgy Somogyi ,  Janos Salat ,  Sandor Boros

发明人： Antonia Jekkel ,  Gabor Ambrus ,  Eva Ilkoy ,  Ildiko Horvath ,  Attila Konya ,  Istvan Szabo ,  Zsuzsanna Nagy ,  Gyula Horvath ,  Julia Mozes ,  Istvan Barta ,  Gyorgy Somogyi ,  Janos Salat ,  Sandor Boros

IPC分类号： C12P7/62 ,  C07C69/30 ,  C12P1/04 ,  C12P7/42 ,  C12P17/06 ,  C12R1/29 ,  C12R1/31 ,  C12N1/21 ,  C12N9/18

CPC分类号： C12R1/29 ,  C12P7/42 ,  C12P17/06

摘要： The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6β-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the biocoversion. The latter comprises the cultivation of a Micromonospora strain which is able to 6β-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.

摘要翻译： 本发明涉及一种由通式（II）化合物制备式（I）化合物的新型微生物方法，其中R代表碱金属或铵离子，通过浸没培养的能够 在好氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物，使式（II）化合物6β-羟化。 后者包括培养微孢子虫菌株，其能够在含有可用碳源和氮源的营养培养基上在25-32℃下将通式（II）化合物（其中R如上定义）6β-羟基化 然后将待转化的底物喂入显影培养物，然后将底物氢化，直到生物转化完成，然后从培养液中分离式（I）化合物，如果需要，将其纯化。