公开(公告)号：US20220233687A1

公开(公告)日：2022-07-28

申请号：US17615493

申请日：2020-03-31

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Qinjian ZHAO ,  Xiaofen HUANG ,  Yike LI ,  Meifeng NIE ,  Siyi CHEN ,  Ningshao XIA

IPC: A61K39/39 ,  A61K39/25 ,  A61P37/04 ,  A61P31/22

Abstract: The present invention pertains to the field of pharmaceutical technology. Specifically, the present invention relates to a zinc risedronate micro/nano adjuvant with sustained-release function formed by mineralization of zinc ions and risedronic acid as main components and its use as a vaccine adjuvant. The present invention also relates to a method for preparing zinc risedronate micro/nano adjuvant. The present invention also relates to a chemical composition, vaccine adjuvant and vaccine composition comprising zinc risedronate micro/nano adjuvant. The present invention also relates to a use of zinc risedronate micro/nano adjuvant as a vaccine adjuvant.

公开(公告)号：US20220193231A1

公开(公告)日：2022-06-23

申请号：US17602214

申请日：2020-04-10

Applicant: XIAMEN INNOVAX BIOTECH CO., LTD. ,  XIAMEN UNIVERSITY

Inventor： Qinjian ZHAO ,  Xiaofen HUANG ,  Siyi CHEN ,  Yike LI ,  Cai ZHANG ,  Ningshao XIA

IPC: A61K39/39 ,  A61K9/14 ,  A61K39/25 ,  A61K39/29 ,  A61P37/04 ,  A61P31/22

Abstract: Disclosed is a zinc zoledronate micro-nanoparticle adjuvant, which contains zinc and zoledronic acid and optionally contains a phosphate and aluminum. The preparation method therefor comprises performing mixed precipitation on a soluble salt solution containing zinc ions, zoledronic acid, and sodium hydroxide. The adjuvant can be used to prepare vaccines, etc.