公开(公告)号：US11339194B2

公开(公告)日：2022-05-24

申请号：US16901410

申请日：2020-06-15

申请人： XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

发明人： Shengxiang Ge ,  Tingdong Li ,  Lianzhi Jia ,  Yijian Li ,  Miaoge Xue ,  Yuanjun Zeng ,  Huirong Pan ,  Jun Zhang ,  Ningshao Xia

IPC分类号： C07K14/005 ,  A61K31/14 ,  A61P1/12 ,  A61K39/12 ,  A61K39/15 ,  A61P31/14 ,  A61P1/00 ,  A61P29/00 ,  C12N7/00 ,  A61K39/00

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

公开(公告)号：US20200308233A1

公开(公告)日：2020-10-01

申请号：US16901410

申请日：2020-06-15

申请人： XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

发明人： Shengxiang Ge ,  Tingdong Li ,  Lianzhi Jia ,  Yijian Li ,  Miaoge Xue ,  Yuanjun Zeng ,  Huirong Pan ,  Jun Zhang ,  Ningshao Xia

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/15 ,  A61P31/14 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  C12N7/00

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

公开(公告)号：US10723767B2

公开(公告)日：2020-07-28

申请号：US15575140

申请日：2016-05-20

申请人： XIAMEN UNIVERSITY ,  Xiamen Innovax Biotech Co., Ltd.

发明人： Shengxiang Ge ,  Tingdong Li ,  Lianzhi Jia ,  Yijian Li ,  Miaoge Xue ,  Yuanjun Zeng ,  Huirong Pan ,  Jun Zhang ,  Ningshao Xia

IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K39/15 ,  A61P31/14 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  A61K39/00

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.