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公开(公告)号：US10544187B2
公开(公告)日：2020-01-28
申请号：US14217166
申请日：2014-03-17
Applicant: Xencor, Inc.
Inventor： Seung Chu , Matthew Bernett , Dilki Wickramarachchi , John Desjarlais
Abstract: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
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公开(公告)号：US10519242B2
公开(公告)日：2019-12-31
申请号：US14214475
申请日：2014-03-14
Applicant: Xencor, Inc.
Inventor： Seung Chu , Matthew Bernett , Dilki Wickramarachchi , John Desjarlais
Abstract: The present invention provides methods and compositions comprising a heterodimeric antibody comprising a first monomer comprising a first variant heavy chain constant region and an anti-CD4 binding moiety. The heterodimeric antibody also comprises a second monomer comprising: a second variant heavy chain constant region and an anti-CD25 binding moiety. In some cases, the pIs of the first and second variant heavy chain constant regions are at least 0.5 logs apart.
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公开(公告)号：US20140294836A1
公开(公告)日：2014-10-02
申请号：US14214475
申请日：2014-03-14
Applicant: Xencor, Inc.
Inventor： Seung Chu , Matthew Bernett , Dilki Wickramarachchi
IPC: C07K16/28
CPC classification number: C07K16/2866 , C07K16/2812 , C07K2317/31 , C07K2317/71 , C07K2317/72 , C07K2317/732
Abstract: The present invention provides methods and compositions comprising a heterodimeric antibody comprising a first monomer comprising a first variant heavy chain constant region and an anti-CD4 binding moiety. The heterodimeric antibody also comprises a second monomer comprising: a second variant heavy chain constant region and an anti-CD25 binding moiety. In some cases, the pIs of the first and second variant heavy chain constant regions are at least 0.5 logs apart.
Abstract translation: 本发明提供包含异二聚体抗体的方法和组合物，所述异二聚体抗体包含包含第一变体重链恒定区和抗CD4结合部分的第一单体。 异二聚体抗体还包含第二单体，其包含：第二变体重链恒定区和抗CD25结合部分。 在一些情况下，第一和第二变体重链恒定区的pI至少为0.5log。
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