公开(公告)号：US12180175B2

公开(公告)日：2024-12-31

申请号：US17475486

申请日：2021-09-15

Applicant: Xi'an Easy Peptide Biotechnology Co., Ltd.

Inventor： Junfeng Zhao ,  Tao Liu

IPC: C07D317/28 ,  C07C67/03 ,  C07C67/08 ,  C07C201/12 ,  C07C231/02 ,  C07C269/06 ,  C07C327/22 ,  C07C327/26 ,  C07C329/04 ,  C07D213/81 ,  C07D213/83 ,  C07D215/48 ,  C07D295/185 ,  C07D333/70 ,  C07J1/00 ,  C07K5/06

Abstract: The present disclosure discloses a water-soluble ynamide coupling reagent and a method for using the water-soluble ynamide coupling reagent in the synthesis of amide, polypeptide, ester and thioester compound. The ynamide coupling reagent has the structure represented by the following formula (I): and in the formula (I), R is one selected from the group consisting of methylsulfonyl, benzenesulfonyl, p-toluenesulfonyl, trifluoroacetyl and other electron withdrawing groups.