公开(公告)号：US20250019401A1

公开(公告)日：2025-01-16

申请号：US18661017

申请日：2024-05-10

Applicant: Xiamen University

Inventor： Kejian WANG ,  Yuqi BAI ,  Fangyi CHEN ,  Hui PENG ,  Huiyun CHEN

IPC: C07K7/08 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10

Abstract: An antimicrobial peptide Bolespleenin of Boleophthalmus pectinirostris and application thereof, and an amino acid sequence of the antimicrobial polypeptide Bolespleenin is shown in SEQ ID NO.01.

公开(公告)号：US20210317172A1

公开(公告)日：2021-10-14

申请号：US17230243

申请日：2021-04-14

Applicant: Xiamen University

Inventor： Kejian WANG ,  Ying YANG ,  Fangyi CHEN ,  Yanchao CHEN ,  Huiyun CHEN ,  Hui PENG

IPC: C07K14/435 ,  A23K20/147 ,  A61K45/06 ,  A61P31/10

Abstract: The present disclosure discloses an antimicrobial peptide Scyreprocin of Scylla paramamosain and a method thereof, wherein an amino acid sequence of the antimicrobial peptide Scyreprocin comprises a sequence shown in SEQ ID NO 01, and the antimicrobial peptide is expressed and purified by using genetic engineering technology. The recombinant antimicrobial peptide Scyreprocin has advantages of wide antimicrobial spectrum, good antimicrobial effect, and rapid germicidal rate, shows great application significance, and has good application in preparation of antimicrobial agents. The recombinant antimicrobial peptide Scyreprocin has no cytotoxicity to mouse hepatocytes AML12, human liver cells L02, and can be safely used for medical treatment or can be used as a feed composition.

公开(公告)号：US20210061865A1

公开(公告)日：2021-03-04

申请号：US16944724

申请日：2020-07-31

Applicant: Xiamen University

Inventor： Kejian WANG ,  Yanchao CHEN ,  Fangyi CHEN ,  Ying YANG ,  Hui PENG ,  Huiyun CHEN

IPC: C07K14/435 ,  A23K10/20

Abstract: Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

公开(公告)号：US20210340179A1

公开(公告)日：2021-11-04

申请号：US17373042

申请日：2021-07-12

Applicant: Xiamen University

Inventor： Kejian WANG ,  Depeng ZHU ,  Hui PENG ,  Fangyi CHEN ,  Huiyun CHEN

IPC: C07K7/06 ,  A61P31/04

Abstract: The present disclosure discloses an antimicrobial peptide AS-hepc3(48-56) of Acanthopagrus schlegelii and method thereof. A molecular formula of the antimicrobial peptide AS-hepc3(48-56) is C48H86N24O10S3, and an amino acid sequence of the antimicrobial peptide AS-hepc3(48-56) is SEQ ID NO: 01.