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1.发明授权Fibrous assemblies for antibody presentation, and multiplexed antigenic analysis using same 有权用于抗体呈递的纤维组件，以及使用其的多重抗原分析公开(公告)号：US08791239B2
公开(公告)日：2014-07-29
申请号：US12990981
申请日：2009-04-07
CPC分类号： A61K9/5169 , B01J19/0046 , B01J2219/00515 , B01J2219/00524 , B01J2219/00527 , B01J2219/00657 , B01J2219/00659 , B01J2219/00666 , B01J2219/00725 , C08L5/08 , G01N33/544
摘要： Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis.
摘要翻译： 包括纤维平台和组氨酸标记的蛋白质的生物功能化纤维和任选的抗体。 壳聚糖是用作纤维平台的纤维。 纤维平台可以用镍处理，或者可以直接连接到组氨酸标记的蛋白质，例如组氨酸标记的链球菌IgG结合蛋白，蛋白G，蛋白质G3T，GFP或RFP。 所得的生物功能化纤维可以通过各种生物制造方法组装成蛋白质纤维组件。 纤维组件，例如织造织物的形式，可用于（i）抗原捕获; （ii）免疫分析和/或（iii）多重分析。 在一个制造中，纤维组件的每个纤维呈现特异性抗体，并且纤维的混合和匹配，例如通过编织来自各种抗体呈递纤维的织物，允许同时捕获多个抗原进行多重分析。
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2.发明申请FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAME 有权用于抗体呈现的纤维组装和使用相同的多重抗原分析公开(公告)号：US20110195860A1
公开(公告)日：2011-08-11
申请号：US12990981
申请日：2009-04-07
CPC分类号： A61K9/5169 , B01J19/0046 , B01J2219/00515 , B01J2219/00524 , B01J2219/00527 , B01J2219/00657 , B01J2219/00659 , B01J2219/00666 , B01J2219/00725 , C08L5/08 , G01N33/544
摘要： Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis.
摘要翻译： 包括纤维平台和组氨酸标记的蛋白质的生物功能化纤维和任选的抗体。 壳聚糖是用作纤维平台的纤维。 纤维平台可以用镍处理，或者可以直接连接到组氨酸标记的蛋白质，例如组氨酸标记的链球菌IgG结合蛋白，蛋白G，蛋白质G3T，GFP或RFP。 所得的生物功能化纤维可以通过各种生物制造方法组装成蛋白质纤维组件。 纤维组件，例如织造织物的形式，可用于（i）抗原捕获; （ii）免疫分析和/或（iii）多重分析。 在一个制造中，纤维组件的每个纤维呈现特异性抗体，并且纤维的混合和匹配，例如通过编织来自各种抗体呈递纤维的织物，允许同时捕获多个抗原进行多重分析。
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