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公开(公告)号：US08202911B2
公开(公告)日：2012-06-19
申请号：US13053161
申请日：2011-03-21
IPC分类号： A61K31/12 , C07C49/587
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 一方面，本发明提供包含治疗有效量的通式（I）化合物的药物组合物，其中R 1 -R 6，R a -R c，Q，Y 1，Y 2和n如本文所定义，其中组合物为 配制成以约0.1mg / kg至约50mg / kg体重的剂量施用于受试者。 另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US08957056B2
公开(公告)日：2015-02-17
申请号：US11597678
申请日：2005-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/395 , A61K31/335 , C07D313/00 , C07D225/02 , A61K31/365 , A61K31/435
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
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