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公开(公告)号：US08957056B2
公开(公告)日：2015-02-17
申请号：US11597678
申请日：2005-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/395 , A61K31/335 , C07D313/00 , C07D225/02 , A61K31/365 , A61K31/435
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
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公开(公告)号：US20090124662A1
公开(公告)日：2009-05-14
申请号：US11597678
申请日：2006-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jon T. Njardarson , Malcolm A.S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jon T. Njardarson , Malcolm A.S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/4523 , A61P35/00 , A61P25/00
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
摘要翻译： 一方面，本发明提供了一种用于治疗受试者中结肠和/或卵巢癌的方法，包括向有需要的受试者施用通式（I）的化合物：其中R1-R6，R，-R，Q， Y1，Y2和n如本文所定义，其中化合物以有效抑制结肠和/或卵巢肿瘤转移的量存在。
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公开(公告)号：US08188141B2
公开(公告)日：2012-05-29
申请号：US11663580
申请日：2005-09-23
IPC分类号： A61K31/38 , A61K31/335 , C07D337/00 , C07D309/00 , C07C49/00
CPC分类号： C07D313/00
摘要： The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
摘要翻译： 本发明提供具有式（I）的化合物：（I）其中n，R 1 -R 5，R a -R b，Q，Y 1和Y 2如本文所定义; 并且另外提供其合成方法，其组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法。
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公开(公告)号：US20090054488A1
公开(公告)日：2009-02-26
申请号：US11663580
申请日：2005-09-23
IPC分类号： A61K31/4523 , C07D405/02 , A61P35/00 , A61P9/00 , A61P37/00 , A61P7/00 , A61P31/00
CPC分类号： C07D313/00
摘要： The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
摘要翻译： 本发明提供具有式（I）的化合物：（I）其中n，R 1 -R 5，R a -R b，Q，Y 1和Y 2如本文所定义; 并且另外提供其合成方法，其组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法。
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