公开(公告)号：US20080026474A1

公开(公告)日：2008-01-31

申请号：US11782660

申请日：2007-07-25

申请人： Xinkang Wang ,  Mei-Yin Hsu ,  Pancras C. Wong

发明人： Xinkang Wang ,  Mei-Yin Hsu ,  Pancras C. Wong

IPC分类号： G01N33/48

CPC分类号： G01N33/86

摘要： Methods for differentiating compounds that modulate the extrinsic and/or intrinsic coagulation pathways are provided. Also provided are methods for identifying a compound that modulates the extrinsic coagulation pathway. In addition, methods for determining an effective dosage of an anticoagulant in a patient are provided.

摘要翻译： 提供了用于分化调节外在和/或固有凝血途径的化合物的方法。 还提供了用于鉴定调节外在凝血途径的化合物的方法。 此外，提供了确定患者抗凝血剂有效剂量的方法。

公开(公告)号：US20050025705A1

公开(公告)日：2005-02-03

申请号：US10896383

申请日：2004-07-22

申请人： Xinkang Wang

发明人： Xinkang Wang

IPC分类号： A61K33/26 ,  A61K49/00

CPC分类号： A61K49/0008 ,  A61K33/26

摘要： The present invention includes animal models useful for the study of thrombosis and the use of such models in drug discovery and development. The present invention relates to the induction of thrombus formation in a murine animal model by contacting a blood vessel with a low concentration of ferric chloride (FeCl3). It is found for the first time in the present invention that the use of low ferric chloride concentrations permits thrombus formation which can be treated by known antithrombotic agents at desirable concentrations. Thus, the present invention permits the study of compounds for their possible use as antithrombotic agents under conditions which provide clinically meaningful results. Compounds discovered using the inventive animal models and methods of treatment using such compounds are also included. Gunmetal mice useful as animal thrombosis models are also included.

摘要翻译： 本发明包括可用于研究血栓形成的动物模型和在药物发现和开发中使用这种模型。 本发明涉及通过使血管与低浓度的氯化铁（FeCl 3）接触来诱导鼠动物模型中的血栓形成。 在本发明中首次发现，使用低氯化铁浓度允许血栓形成，其可以通过已知抗凝血剂以所需浓度处理。 因此，本发明允许在提供临床有意义的结果的条件下研究化合物作为抗血栓形成剂的可能用途。 还包括使用本发明的动物模型发现的化合物和使用这些化合物的治疗方法。 也可以使用作为动物血栓形成模型使用的金枪鼠。

公开(公告)号：US06214854B1

公开(公告)日：2001-04-10

申请号：US09456866

申请日：1999-12-08

申请人： Xinkang Wang ,  Tian-Li Yue

发明人： Xinkang Wang ,  Tian-Li Yue

IPC分类号： A61K3140

CPC分类号： C07D209/88 ,  A61K31/00 ,  A61K31/403

摘要： This invention relates to a method for inhibiting stress-activated protein kinases (SAPKs) which comprises administering to a mammal in need thereof an effective amount of a compound which is a dual non-selective &bgr;-adrenoceptor and &agr;1-adrenoceptor antagonist.

摘要翻译： 本发明涉及一种抑制应激活化蛋白激酶（SAPK）的方法，其包括向有需要的哺乳动物施用有效量的双重非选择性β-肾上腺素能受体和α1-肾上腺素受体拮抗剂的化合物。