公开(公告)号：US20180156816A1

公开(公告)日：2018-06-07

申请号：US15888455

申请日：2018-02-05

Applicant: Xiujuan Hao ,  Isaac A Angres

Inventor： Xiujuan Hao ,  Isaac A Angres

IPC: G01N33/68 ,  C07H19/16 ,  C07K16/44 ,  G01N33/574 ,  A61K31/7076

CPC classification number: G01N33/6812 ,  A61K31/7076 ,  C07H19/16 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/33 ,  G01N33/57484 ,  G01N2440/12 ,  G01N2800/105 ,  G01N2800/7033 ,  Y02A50/423

Abstract: The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US09885723B2

公开(公告)日：2018-02-06

申请号：US14732775

申请日：2015-06-07

Applicant: Xiujuan Hao ,  Isaac A Angres

Inventor： Xiujuan Hao ,  Isaac A Angres

IPC: A61K31/7076 ,  G01N33/68 ,  C07H19/16 ,  C07K16/44 ,  G01N33/574

CPC classification number: G01N33/6812 ,  A61K31/7076 ,  C07H19/16 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/33 ,  G01N33/57484 ,  G01N2440/12 ,  G01N2800/105 ,  G01N2800/7033 ,  Y02A50/423

Abstract: The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US10656159B2

公开(公告)日：2020-05-19

申请号：US15888455

申请日：2018-02-05

Applicant: Xiujuan Hao ,  Isaac A Angres

Inventor： Xiujuan Hao ,  Isaac A Angres

IPC: G01N33/68 ,  C07K16/44 ,  A61K31/7076 ,  C07H19/16 ,  G01N33/574

Abstract: The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US09958447B2

公开(公告)日：2018-05-01

申请号：US14457099

申请日：2014-08-11

Applicant: Xiujuan Hao ,  Isaac A Angres

Inventor： Xiujuan Hao ,  Isaac A Angres

IPC: C07K16/44 ,  G01N33/574 ,  C07H19/16 ,  C07D473/02 ,  C07D493/04 ,  C07D519/00 ,  G01N33/53

CPC classification number: G01N33/57484 ,  C07D473/02 ,  C07D493/04 ,  C07D519/00 ,  C07H19/16 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/33 ,  G01N2800/7033

Abstract: The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

公开(公告)号：US09877982B2

公开(公告)日：2018-01-30

申请号：US14218928

申请日：2014-03-18

Applicant: Xiujuan Hao ,  Isaac A Angres

Inventor： Xiujuan Hao ,  Isaac A Angres

IPC: G01N33/574 ,  A61K31/7076

CPC classification number: A61K31/7076 ,  G01N33/57484 ,  G01N2800/7033

Abstract: A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual.

公开(公告)号：US08309024B2

公开(公告)日：2012-11-13

申请号：US12386823

申请日：2009-04-23

Applicant: Volodymyr I Redko ,  Elena M Shembel ,  Volodymyr S Khandetskyy ,  Dayal T Meshri ,  Isaac A Angres ,  Robert Adams ,  Dmytro Sivtsov ,  Oxana V Redko ,  Tymofiy V Pastushkin

Inventor： Volodymyr I Redko ,  Elena M Shembel ,  Volodymyr S Khandetskyy ,  Dayal T Meshri ,  Isaac A Angres ,  Robert Adams ,  Dmytro Sivtsov ,  Oxana V Redko ,  Tymofiy V Pastushkin

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N27/221

Abstract: A system for non-destructive determination of the degree of fluorination in carbon monofluoride (CFx) during the process of CFx synthesis is described. The system includes a measuring generator containing a capacitive sensor for measuring a respective capacitance, a base generator containing a capacitive sensor for measuring a base capacitance, and a processor for determining a difference between the respective capacitance and the base capacitance. The system is configured to determine the degree of fluorination based on the difference between the respective capacitance and the base capacitance.

Abstract translation: 描述了在CFx合成过程中用于非破坏性测定单氟化碳（CFx）中的氟化度的系统。 该系统包括测量发生器，其包含用于测量相应电容的电容传感器，包含用于测量基本电容的电容式传感器的基座发生器，以及用于确定各个电容和基极电容之间的差的处理器。 该系统被配置为基于相应电容和基极电容之间的差来确定氟化度。